黄连素的降糖机制及临床应用新进展  

New progress inhypoglycemic mechanism and clinical application of berberine

作　　者：谭学莹[1] 赵林双[2] 胡静波[3] 

机构地区：[1]浙江省余姚市人民医院内分泌科,315400 [2]广州军区武汉总医院内分泌科 [3]浙江大学药学院

出　　处：《中国糖尿病杂志》2015年第12期1131-1133,共3页Chinese Journal of Diabetes

基　　金：湖北省重点攻关课题(2006AA301B61-2)

摘　　要：黄连素是从中药黄柏、黄连、三棵针等植物药材中提取出来的生物碱。近年来黄连素的药理作用得到了广泛深入的研究,如抗感染、抗心律失常、保护缺血心肌、降血压、抗肿瘤及抗获得性免疫缺陷综合征(HIV)等作用,尤其对其降血糖作用的报道日渐增多,但其降糖作用机制尚不明确。本文就目前黄连素可能的降糖作用机制及临床疗效观察进行综述。Berberine is akind of alkaloids extracted from Chinese herb medicine in cludingphellod endron,coptis and radix berberidis.In recent years,the pharmacological effects of berberinewas investigated extensively including anti-infection,anti-arrhythmia,protection of ischemic myocardium,anti-hypertension,anti-tumor,anti-HIV.And there are increasing reports about its hypoglycemic effect,but its mechanism remains unclear.Here we summarize the possible mechanism of hypoglycemic effect and clinical efficacy of berberine.

关 键 词：黄连素 糖尿病 2型 降血糖作用 

分 类 号：R259[医药卫生—中西医结合]