Par3蛋白在胶质瘤中的表达及其临床病理学意义  

The Expression and Clinical Pathological Significances of Par3 in Glioma

作　　者：胡萍[1,2] 任年军[2] 沈华[2] 黄莱[2] 胡敏予[1] 

机构地区：[1]中南大学公共卫生学院,湖南长沙410008 [2]中南大学湘雅医学院附属肿瘤医院,湖南长沙410013

出　　处：《肿瘤药学》2015年第6期440-443,共4页Anti-Tumor Pharmacy

摘　　要：目的 检测Partitioning defective 3（Par3）蛋白在胶质瘤组织中的表达,并分析其临床病理学意义。方法 收集70例不同临床分期及不同分化程度胶质瘤组织及20例正常脑组织标本,应用免疫组化技术检测Par3蛋白的表达,并分析其与胶质瘤患者临床病理特征的相关性。结果 与正常脑组织相比,胶质瘤组织中Par3蛋白表达水平显著降低（P〈0.05）。Ⅲ~Ⅳ级胶质瘤组织中Par3蛋白的表达明显低于Ⅰ~Ⅱ级胶质瘤（P〈0.05）。Par3的表达水平与患者的年龄、性别以及病理组织学类型无显著相关性,但与胶质瘤临床分级显著相关（P=0.008）。结论 Par3蛋白在胶质瘤中呈低表达,并与胶质瘤的恶性程度密切相关。Objective To explore the role of Par3 in the development of glioma by analysis of the expression of Par3 in glioma tissue. Methods A total of 70 cases of human glioma tissue with different clinical stages and differentiation histolog- ical types and 20 cases of normal brain tissue were selected. We detected the expression of Par3 by immunohistochemistry method, and analyzed its correlation with the clinicopathologic features of glioma patients. Results Compared with normal brain tissue, the expression of Par3 protein in glioma tissue decreased significantly （P〈0.05）. The expression level of Par3 was significantly lower at stage III- IV than that at stage I - II （P〈0.05）. The expression of Par3 presented no correlation with the age, sex and histological types of patients, but had significant correlation with the clinical stages of glioma （P = 0.008）. Conclusion The Par3 was lowly expressed in glioma tissue and involved in the development and progression of glioma. It was closely correlated with the malignancy of human glioma.

关 键 词：胶质瘤 PAR3 侵袭 临床分期 

分 类 号：R739.41[医药卫生—肿瘤]