伴攻击行为酒精依赖患者的神经认知功能特征性研究  

THE CHARACTERISTIC OF THE NEUROCOGNITIVE FUNCTION IN ALCOHOL- DEPENDENT PATIENTS WITH AGGRESSIVE BEHAIORS

作　　者：周旭辉[1] 刘学军[1] 郭育君[1] 罗琼[1] 周霞峰[1] 侯超[1] 杨俊[1] 黄赛平[1] 张媚[1] 

机构地区：[1]湖南省脑科医院湖南中医药大学临床医学院,长沙410007

出　　处：《中国药物依赖性杂志》2015年第6期436-441,共6页Chinese Journal of Drug Dependence

基　　金：湖南省自然科学青年基金(2015JJ3095);湖南省卫生计生委科研计划课题(C2015-44);湖南省中医药管理局重点科研项目(201431);湖南省卫生厅计划项目(B2013-086);湖南省中医药科研计划项目(201278)

摘　　要：目的:探讨伴攻击行为酒精依赖患者的神经认知功能损害特征。方法:对伴或不伴攻击行为的酒精依赖患者各60例和健康对照60例,采用韦氏记忆量表、Stroop测验以及威斯康星卡片分类测验工具(WCST-M测验),分别对其记忆、注意和执行功能进行测试。结果:伴攻击行为酒依赖者的记忆商数(86.36±s 8.09)显著性低于不伴攻击行为酒精依赖组(93.52±s 9.92),尤其以视觉再认、视觉再生、理解记忆和背诵数目为甚(P<0.01);伴攻击行为酒精依赖者的Stroop总时间、ST-C中不正确数和纠正数高于不伴攻击行为酒精依赖组(P<0.01);伴攻击行为酒精依赖者WCST-M测验的分类错误数、持续错误总数高于不伴攻击行为酒精依赖(P<0.01或P<0.05),差异有统计学意义。结论:本研究结果提示,伴攻击行为酒精依赖者较不伴攻击行为酒精依赖者在记忆、注意和执行功能等神经认知功能方面损害更严重。Objective： To investigate the characteristic of the neurocognitive function in alcohol- dependent patients with aggressive behaviors.Methods： The alcohol- dependent patients with aggressive behaviors（ AD- ABs,n = 60） or without aggressive behaviors（ AD- NABs,n = 60） and age / education- matched healthy control subjects（ HCs,n = 60） are assessed with the neuropsychological tests in Changsha,China. The tools included Wechsler Memory scale- Revised test（ WMS）,Stroop test（ C,CW） and Wisconsin card sorting test（ WCST- M）.Results： The memory quotient and the scores on such factors as vision recognition,design reproduction,story recall,as well as digit span of the AD- ABs group were significant lower than those in the AD- NABs group（ P 〈0. 01）. There were significant differences between the two groups in the time in Stroop test（ C,CW）,the number of errors and rectification in Stroop- C test,the AD- NABs group had more time spent in Stroop test（ C,CW）,and more number of errors and rectification in Stroop- C test（ P 〈0. 01）. Furthermore,the AD- ABs grouphad more total errors and perseverative errors in WCST than the AD- NABs group,the difference was statistical significant（ P 〈0. 01 or P 〈0. 05）.Conclusion： There was certain cognitive dysfunction,such as memory,attention and executive function in the alcohol- dependent patients with aggressive behaviors in our study. The impairment of cognitive function,which was caused by alcohol abuse,continued to aggravate with aggressive behaviors.

关 键 词：酒精依赖 攻击行为 神经认知功能 记忆 注意 

分 类 号：R749[医药卫生—神经病学与精神病学]