不同药物治疗白内障超声乳化术后干眼症的临床效果  

Clinical effect of drug therapy for dry eye syndrome after phacoemulsification

作　　者：刘晓熹[1] 

机构地区：[1]重庆市中医院临床体检中心,重庆400032

出　　处：《中国医药导报》2015年第36期125-128,132,共5页China Medical Herald

摘　　要：目的探讨不同药物治疗白内障超声乳化术后干眼症的临床效果。方法回顾性分析2013年1月．2015年1月于重庆市中医院行白内障超声乳化联合人工晶体植入术后发生干眼症患者100例（100眼）的临床资料。根据治疗方法不同将所有患者分为四组：聚乙二醇组、聚丙烯酸组、玻璃酸钠组和对照组，每组25例。所有患者均行白内障超声乳化术联合人工晶体植入。术后对照组采用常规治疗，其他三组在对照组基础上分别加用聚乙二醇滴眼液、聚丙烯酸眼胶、玻璃酸钠滴眼液点术眼，每天4次，给药1个月。观察比较各组患者术后1、2、3、4周的干眼症状、泪膜破裂时间、Schi~aerI实验、角膜荧光素染色及术后4周的治疗效果。结果四组不同时期干眼症状评分、泪膜破裂时间、Schirmel·I实验比较，差异均有统计学意义（P〈0．05），其中，以玻璃酸钠组干眼症状评分最低，泪膜不稳定患者及SchirmerI实验阳性患者比例最少，差异有统计学意义（P〈0．05）。四组不同时期角膜荧光素染色得分比较，差异均无统计学意义（P〉o．05）。治疗4周后，四组临床总有效比较，差异均有统计学意义（P〈0．05）；其中，玻璃酸钠组总有效率达100％。结论白内障超声乳化术联合人工晶体植入可能对泪膜有一定影响，引发干眼症，应用常规治疗联合人工泪眼治疗效果较优，特别是玻璃酸钠滴眼液较其他药物疗效更优。Objective To discuss the clinical effect of different drugs therapy for dry eye syndrome after phacoemulsi- fication. Methods Clinical data of 100 patients （100 eyes） with dry eye syndrome after phacoemulsification combined with intraocular implantation in Chongqing Traditional Chinese Medicine Hospital from January 2013 to January 2015 was analyzed retrospectively. According to different treatments, the patients were divided into four groups： polyethylene glycol group, polyacrylic acid group, sodium hyaluronate group and control group, with 25 cases in each group. All pa- tients were given phacoemulsification combined with intraocular implantation. After surgery, patients in the control group were given conventional therapy, on the basis of the control group, the other three groups were given Polyethy- lene Glycol Eye Drops, Polyacrylic Acid Eye Gel, Sodium Hyaluronate Eye Drops, 4 times a day, for 1 month. The dry eye symptom scores, break-up time, Schirmer I test, cornea fluorescein staining 1, 2, 3, 4 weeks after surgery and therapeutic effect 4 week after surgery in the four groups were observed and compared. Results The dry eye symptom scores, break-up time, Schirmer I test in different time of the four groups were compared, the differences were statisti- cally significant （P 〈 0.05）, among which, the dry eye symptom score in the sodium hyaluronate group was the lowest, and the patients proportion of tear film instability and positive Schirmer I test were the least, with statistically signifi- cant differences （P 〈 0.05）. The eornea fluorescein staining was compared among the four groups, the differences were not statistically significant （P 〉 0.05）. After treatment for 4 weeks, the differences of clinical total effective in the four groups were statistically significant （P 〈 0.05）, the total effective rate in the sodium hyaluronate group was 100%. Conclusion Phacoemulsification combined with intraocular implantation has influence on tear film, may cause dry eyes, The effects o

关 键 词：干眼症 白内障超声乳化术 聚乙二醇滴眼液 聚丙烯酸眼胶 玻璃酸钠滴眼液 

分 类 号：R776.1[医药卫生—眼科]