顽固性功能性便秘病人免疫功能的变化  

The changes of system immune function in patients with refractory functional constipation

作　　者：黄裕[1] 陈启仪[1] 姜军[1] 冯啸波[1] 倪玲[1] 史益凡 李宁[1] 

机构地区：[1]第二军医大学南京临床医学院(南京军区南京总医院)解放军普通外科研究所,江苏南京210002

出　　处：《肠外与肠内营养》2015年第6期340-342,共3页Parenteral & Enteral Nutrition

基　　金：全军临床高新技术重大项目(2010gxjs025);江苏省临床医学科技专项基金(BL2012006)

摘　　要：目的:探讨顽固性功能性便秘病人免疫功能的变化。方法:选取入住我院的顽固性功能性便秘病人60例(便秘组)和入院行痔疮和低位肛瘘病人60例(对照组)。入院后第1天,抽血检测免疫球蛋白(Ig A、Ig G和Ig M)、C反应蛋白(CRP)、促炎因子(TNF-α、IL-6)、T淋巴细胞亚群(CD3+、CD4+CD3+、CD8+CD3+、CD4+/CD8+和HLA-DR)水平。结果:便秘组病人Ig G和Ig M、TNF-α和IL-6的浓度明显高于对照组,CD3+和CD8+CD3+表达明显低于对照组,CD4+/CD8+表达明显高于对照组。结论:顽固性功能性便秘病人出现明显的免疫功能紊乱和免疫炎症反应状态。Objective： To investigate the changes of immune function in patients with refractory chronic functional constipation. Methods： 60 patients with refractory functional constipation were selected as experimental group and control group was 60 patients with haemorrhoids and low anal fistula.The immunoglobulin（ Ig A,Ig G and Ig M）,CRP,TNF-α,IL-6,T lymphocyte subsets（ CD3＋,CD4＋CD3＋,CD8＋CD3＋and CD4＋/ CD8＋） and HLA-DR level were measured. Results： The Ig G and Ig M,TNF-α,IL-6 and CD4＋/ CD8＋were significantly higher and CD3＋and CD8＋CD3＋was significantly lower in experimental group than those in the control group. Conclusion： The immune function in patients with refractory functional constipation is in a state of disorder.

关 键 词：顽固性功能性便秘 免疫功能 肠道菌群 

分 类 号：R574.62[医药卫生—消化系统]