黄腊果藤茎化学成分的分离与鉴定(Ⅱ)  

Isolation and identification of chemical constituents from stems of Stauntonia brachyanthera Hand.-Mazz.(Ⅱ)

作　　者：陈超 陆丁 孟大利[3] 

机构地区：[1]上海思达医药化工科技有限公司,上海201318 [2]西安利君制药有限责任公司,陕西西安710077 [3]沈阳药科大学基于靶点的药物设计与研究教育部重点实验室,辽宁沈阳110016

出　　处：《沈阳药科大学学报》2015年第12期941-944,共4页Journal of Shenyang Pharmaceutical University

基　　金：国家自然科学基金资助项目(81073154)

摘　　要：目的研究黄腊果(Stauntonia brachyanthera Hand.-Mazz.)藤茎的化学成分。方法利用溶剂萃取法、反复硅胶柱色谱、Sephadex LH-20柱色谱、开放ODS柱色谱、制备型高效液相色谱法等各种方法进行化合物的分离纯化,并采用波谱学技术进行结构鉴定。结果从黄蜡果藤茎的体积分数为70%的乙醇提取物中分离得到6个化合物,分别鉴定为3-O-α-L-吡喃阿拉伯糖-30-去甲齐墩果烷-12,20(29)-二烯-28-羧酸(3-O-α-L-arabinopyranosy-akebonic acid,1)、cyclo-olivil-9-O-β-glucopyranoside(2)、staunoside C[(+)-1-hydroxysyringaresinol-1-β-D-glucoside](3)、ficuscarpanoside B(4)、ficuscarpanoside A(5)、2-(3,4-二羟基苯基)乙基-β-D-吡喃葡萄糖苷([2-(3,4-dihydroxyphenyl)ethyl-β-D-glucopyranoside],6)。结论化合物1-3、6为首次从野木瓜属植物中分离得到,化合物4和5为首次从黄腊果中分离得到。Objective To study the chemical constituents of stems of Stauntonia brachyanthera Hand.-M azz.Methods The compounds were isolated by silica gel column chromatography,Sephadex LH-20 column chromatography,ODS column chromatography,and HPLC,and their structures were determined on the basis of spectral analysis. Results Six compounds were obtained and identified as 3-O-α-L-arabinopyranosy-akebonic acid（ 1）,cyclo-olivil-9-O-β-glucopyranoside（ 2）,staunoside C [（ ＋）-1-hydroxysyringaresinol-1-β-D-glucoside]（ 3）,ficuscarpanoside B（ 4）,ficuscarpanoside A（ 5） and[2-（ 3,4-dihydroxyphenyl） ethyl-β-D-glucopyranoside]（ 6）,respectively. Conclusions Compounds 1- 3 and 6 are isolated from this genus firstly,while compounds 4 and 5 are isolated from this herb for the first time.

关 键 词：黄腊果 化学成分 结构鉴定 

分 类 号：R914[医药卫生—药物化学]