乳腺癌组织中凋亡抑制蛋白Apollon的表达及其临床意义  

Expression of apoptosis protein inhibitor Apollon in breast cancer tissue and its clinical significance

作　　者：陈建发 岳志强 傅明 莫友 周淑蓉 

机构地区：[1]解放军第四二二中心医院普通外科,广东湛江524009

出　　处：《中华乳腺病杂志（电子版）》2015年第5期312-315,共4页Chinese Journal of Breast Disease(Electronic Edition)

基　　金：湛江市财政资金科技专项(2012C0302)

摘　　要：目的研究乳腺癌组织中凋亡抑制蛋白Apollon免疫组化表达及临床意义。方法回顾性收集解放军第四二二医院2010年1月至2014年12月手术切除的女性乳腺癌组织标本66例,采用免疫组织化学法检测66例乳腺癌组织中Apollon、HER-2及survivin的表达。采用Kendall等级相关检验分析Apollon表达与HER-2表达、survivin表达、肿瘤大小及淋巴结状态之间的相关性。结果在乳腺癌组织中Apollon、HER-2及survivin的阳性表达率分别为59.1%(39/66)、31.8%(21/66)及39.4%(26/66)。Apollon表达与HER-2表达(tau-b=0.370,P=0.003)、survivin表达(tau-b=0.292,P=0.018)、肿瘤大小(tau-b=0.322,P=0.009)及淋巴结状态(tau-b=0.424,P=0.001)显著相关。结论 Apollon表达与HER-2表达、Survivin表达、肿瘤大小及淋巴结状态有关,其可能是一个与乳腺癌发展相关的潜在分子标志物。Objective To investigate the immunohistochemical expression of apoptosis protein inhibitor Apollon in breast cancer tissue and its clinical significance. Methods We retrospectively analyzed the female breast cancer tissue specimens from 66 cases treated in No. 422 Hospital of PLA from January 2010 and December 2014. The expressions of Apollon, HER-2 and survivin were assessed immnnohistochemically. The correlation of ApoUon expression with HER-2 expression, survivin expression, tumor size and lymph node status was analyzed using Kendall rank correlation test. Results The positive rates of Apollon, HER-2 and survivin in breast cancer tissue were 59. 1% （39/66）, 31.8% （21/66） and 39.4% （26/66）, respectively. Apollon expression was significantly associated with HER-2 expression （ tau-b = O. 370, P = 0. 003 ）, survivin expression （ tan-b = 0. 292, P = 0. 018）, tumor size （ tau-b = 0. 322, P = 0. 009） and lymph node status （ tau-b = 0. 424, P = 0. 001）. Conclusions Apollon expression is associated with HER-2 expression, survivin expression, tumor size and lymph node status. Apollon may be a potential molecular marker in the development of breast cancer.

关 键 词：乳腺肿癌 凋亡抑制蛋白质类 免疫组织化学 预后 

分 类 号：R737.9[医药卫生—肿瘤]