肿瘤标志物SCCA、TPS、NSE和CYFERA21-1检测在肺癌中的临床价值  

Clinical value of tumor markers SCCA,TPS,NSE and CYFERA21-1 detection in diagnosis of lung cancer

作　　者：潘秋荣[1] 徐勤燕[1] 

机构地区：[1]南京中医药大学附属常州中医医院检验科,江苏常州213003

出　　处：《国际检验医学杂志》2015年第24期3543-3544,共2页International Journal of Laboratory Medicine

摘　　要：目的探讨肿瘤标志物鳞状上皮细胞癌抗原(SCCA)、组织多肽特异性抗原(TPS)、神经原特异性烯醇化酶(NSE)和细胞角蛋白-19片断抗原(CYFERA21-1)检测在肺癌患者中的临床价值。方法随机选择2012年2月至2014年10月来该院初诊确诊肺癌患者70例(其中鳞癌26例、腺癌23例、小细胞癌21例),肺良性疾病患者40例(其中肺炎19例、支气管炎16例、肺结核5例),同期健康体检者30例进行SCCA、TPS、NSE和CYFERA21-1的检测。然后进行统计学分析。结果肺癌组血清肿瘤标志物SCCA、TPS、NSE和CYFERA21-1水平均明显高于肺良性疾病组和健康对照组,差异有统计学意义(P<0.05)。血清肿瘤标志物SCCA、TPS、NSE和CYFERA21-1在肺癌不同组织类型中表达水平不同。SCCA、CYFERA21-1在鳞癌中表达水平高,与其他两组病理类型肺癌相比较,差异有统计学意义(P<0.05);NSE在小细胞肺癌中水平最高,与其他两组病理类型肺癌相比较,差异有统计学意义(P<0.05);TPS在不同病理类型之间比较,差异没有统计学意义(P>0.05)。通过SCCA、TPS、NSE和CYFERA21-1四项联合检测,对肺癌诊断检测的敏感度和准确度有了很大提高。结论进行SCCA、TPS、NSE和CYFERA21-1的联合检测对肺癌的诊断、病理分类及协助临床治疗具有很高的临床价值。Objective To explore the clinical value of tumor marker squamous cell carcinoma antigen（SCCA）,tissue polypeptide specific antigen（TPS）,neuron-specific enolase（NSE）,cytokeratin fragment 19（CYFRA21-1）detections in the patient with lung cancer.Methods 70 patient with newly diagnosed lung cancer（including 26 cases of squamous cell carcinoma,23 cases of adenocarcinoma and 21 cases of small cell carcinoma）,40 cases of lung benign diseases and contemporaneous 30 individuals undergoing the physical examination were randomly selected as the lung cancer group,lung benign disease group and healthy control group respectively.Serum tumor markers of SCCA,TPS,NSE and CYFERA21-1were detected in all cases.Then the detection results were performed the statistical analysis.Results The levels of SCCA,TPS,NSE and CYFERA21-1in the lung cancer group were significantly higher than those in the lung benign diseases group and healthy control group,the differences were statistically significant（P〈0.05）.The expression levels of serum SCCA,TPS,NSE and CYFERA21-1 were different in different histological types of lung cancer.SCCA and CYFERA21-1were highly expressed in squamous cell carcinoma,which showed the statistical difference compared with other two pathological types of lung cancer（P〈0.05）;the expression level of NSE was highest in small cell lung cancer,which showed the statistical difference compared with other two pathological types of lung cancer（PP〈0.05）;the TPS expression level had no statistical difference among different pathological types of lung cancer（P〉0.05）.The combination detection of SCCA,TPS,NSE and CYFERA21-1greatly increased the sensitivity and accuracy for diagnosing lung cancer.Conclusion The combination detection of SCCA,TPS,NSE and CYFERA21-1has very high clinical value for the diagnosis,pathological typing and assisted clinical therapy of lung cancer.

关 键 词：肺癌 鳞状上皮细胞癌抗原 组织多肽特异性抗原 神经原特异性烯醇化酶 细胞角蛋白-19片断抗原 

分 类 号：R734.2[医药卫生—肿瘤]