转化生长因子基因多态性与多发性骨髓瘤的相关性  

Correlation between TGF gene polymorphism and multiple myeloma

作　　者：韩富秋[1] 杨国东[1] 王仕超[1] 董海荣[1] 

机构地区：[1]呼和浩特市第一医院检验科,内蒙古呼和浩特010030

出　　处：《国际检验医学杂志》2015年第24期3554-3555,共2页International Journal of Laboratory Medicine

摘　　要：目的探讨转化生长因子(TGF)基因单核苷酸多态性与多发性骨髓瘤(MM)的关系。方法采用病例对照研究,选取多发性骨髓瘤患者55例和健康对照55例,采用聚合酶链反应(PCR)-连接酶检测反应(LDR)进行基因型、等位基因型检测,并进一步进行测序分型。结果 MM患者TGF两位点基因型频率、等位基因频率、联合单倍体分型中各型的频率与对照组比较差异均无统计学意义(P>0.05)。结论转化生长因子基因单核苷酸多态性与多发性骨髓瘤的发生以及亚型没有明显的相关性。Objective To investigate the relationship between transforming growth factor gene（TGF）single nucleotide polymorphism（SNP）and multiple myeloma（MM）.Methods The case control study was performed,55 patients with MM and 55 healthy controls were selected.The genotype and allele detections were performed by adopting the polymerase chain reaction（PCR）and the ligase detection reaction（LDR）respectively.Then the sequencing based typing was further conducted.Results There were no statistically significant differences in the two loci genotype frequencies,allele frequencies and genotype frequencies in joint haploid typing between the MM group and the control group（P〉0.05）.Conclusion SNP of TGF gene has no obvious correlation with the occurrence of MM and subtypes.

关 键 词：多发性骨髓瘤 单核苷酸多态性 转化生长因子基因 

分 类 号：R733.3[医药卫生—肿瘤]