难治性精神分裂症患者脑灰质的体积下降——基于体素的形态学研究(VBM)  

Decrease of gray matter volume in treatment-refractory schizophrenia——voxel based morphometry(VBM) study

作　　者：徐西嘉[1] 史晓蒙 唐劲松[2] 王筱兰[1] 孙静[1] 姚辉[1] 

机构地区：[1]南京医科大学附属脑科医院精神科,南京210029 [2]中南大学湘雅二医院精神科

出　　处：《国际精神病学杂志》2015年第6期1-4,共4页Journal Of International Psychiatry

基　　金：南京市医学科技发展资金资助项目(QRX11121;ZKX08034);江苏省卫生厅面上项目(H200875);国家临床重点专科建设项目(精神科;卫生部医政司2011-873);江苏省医学重点学科(精神病学;江苏省卫生厅2011-12)

摘　　要：目的了解难治性精神分裂症患者的脑灰质改变,以及这种脑灰质改变与症状相关关系。方法采用基于体素的形态学分析方法对24名难治性精神分裂症患者和21名相匹配的正常对照者进行两组之间的脑灰质体积比较。结果本研究发现,与对照组相比,难治性精神分裂症患者的左侧嗅觉皮层、双侧岛叶、右侧前扣带回灰质体积下降(P<0.05,FWE纠正后),但是进一步的感兴趣区分析未发现这些脑区灰质体积变化与临床症状存在相关性。结论难治性精神分裂症存在较为广泛的皮层受损,受损部位包括左侧嗅觉皮层、双侧岛叶和右侧前扣带回。Objective To measure the gray matter changes in treatment-refractory schizophrenic patients and to understand the correlations between gray matter changes and clinical characteristic in those patients. Methods The present study used voxel based morphometry（ VBM） in conjunction with statistical parametric mapping on the structural magnetic resonance images of treatment-refractory schizophrenia patients（ n = 24） and control individuals（ n = 21） to assess differences between the two groups in gray matter volume. Results We found a decrease in gray matter volume in left olfactory,bilateral insula and right anterior cingulate of schizophrenia patients in comparison to controls（ P〈0. 05,FWE corrected）. However,we did not found any correlation between gray matter changes and clinical characteristic in those patients. Conclusion Treatment-refractory schizophrenia patients have extensive gray matter decrease in left olfactory,bilateral insula and right anterior cingulate.

关 键 词：难治性精神分裂症 脑灰质 基于体素的形态学 

分 类 号：R749.3[医药卫生—神经病学与精神病学]