糖尿病患者超声乳化白内障吸除术后干眼症相关指标变化的临床观察  

Clinical observation on the changes of xerophthalmia related indexes in diabetic patients after phacoemulsification

作　　者：苗晓晴[1] 黄祖烽 杨筱曦[2] 

机构地区：[1]广东省湛江中心人民医院眼科,524037 [2]中山大学附属第六医院眼科,510655

出　　处：《中华眼科医学杂志（电子版）》2015年第6期18-23,共6页Chinese Journal of Ophthalmologic Medicine(Electronic Edition)

基　　金：广东省自然科学基金-博士启动(2014A030310085)

摘　　要：目的了解糖尿病(DM)患者超声乳化白内障吸除术后干眼症相关指标的变化。方法收集2013年10月至2015年1月期间广东省湛江中心人民医院眼科行超声乳化白内障吸除术的80例(80只眼)白内障患者的临床资料。术前对所有患者进行基础泪液分泌试验(SIt)及泪膜破裂时间(BUT)检测,均在正常范围;患者除视物模糊外,无其他主观不适。按是否患合并DM将患者分为实验组38例(38只眼)和对照组42例(42只眼)。实验组和对照组患者的SIt和BUT变化值以均数±标准差(x珋±s)的形式表示,并采用配对t检验进行组内比较;采用独立样本t检验的统计学方法进行组间比较。结果实验组术前3 d、术后1周和术后3个月SIt平均值分别为(10.58±0.89)mm、(6.08±0.63)mm及(9.63±1.03)mm,术后1周及3个月与术前相比,差异有统计学意义(t1=25.43,4.31;P1<0.05)。实验组术前3 d、术后1周和术后3个月BUT平均值分别为(9.40±1.21)s、(4.88±1.90)s及(7.79±1.22)s,术后1周及3个月与术前相比,差异有统计学意义(t1=12.37,5.78;P1<0.05)。对照组术前3 d、术后1周和术后3个月SIt平均值分别为(11.02±0.87)mm、(8.52±1.11)mm及(10.14±0.95)mm,术后1周及3个月与术前相比,差异有统计学意义(t2=11.49,4.42;P2<0.05)。对照组术前3 d、术后1周和术后3个月BUT平均值分别为(9.60±0.73)s、(5.17±0.44)s及(7.83±0.73)s,术后1周及3个月与术前相比,差异有统计学意义(t2=33.68,11.11;P2<0.05)。术后1周实验组SIt下降(4.50±1.03)mm,对照组下降(2.50±0.94)mm,两组比较,差异有统计学意义(t=6.63,P<0.05)。术后1周实验组BUT下降(4.60±1.68)s,对照组下降(4.43±0.83)s,两组比较,差异有统计学意义(t=2.30,P<0.05)。术后3个月实验组SIt下降(0.95±0.61)mm,对照组SIt下降(0.88±0.59)mm,两组比较,差异无统计学意义(t=0.49,P>0.05)。术后3个月实验组BUT下降(1.69±0.75)s,对照组下降(1.76±0.58)s,两组比较,差异无统计学意义(t=0.04,P>0.05)。术后1Objective Understanding of diabetes mellitus （DM） patients with phacoemulsification changes in postoperative dry eye related indicators. Method Clinical data of 80 cases （ 80 eyes） of cataract patients with cataract surgery were collected from January 2015 to October 2013 in Zhanjiang People＇s Central Hospital of Guangdong province. Before the operation all the patients underwent Schirmer test （Sit） and tear film break-up time （BUT） detection,were in the normal range;patients except blurred vision, no other subjective discomfort. The patients were divided into experimental group （38 cases） and control group （42 eyes） in 42 cases （ 38 eyes ）, according to whether the patients were complicated with DM. The experimental group and the control group of patients with Sit and BUT changes the value of mean standard deviation （x＋s） representation, and using the paired t test to compare the group;using a statistical method of independent sample t test were compared between the groups. Results In the experimental group,the average value of 3 d before surgery,1 weeks and 3 months after surgery were （10.58±0.89） mm, （6.08±0. 63 ）mm and （ 9.63± 1.03 ） mm, and the difference was statistically significant （ t1 = 25.43,4.31 ; P1 〈0. 05 ） after 1 weeks and 3 months after surgery. In the experimental group, the average value of 3 d before surgery, l weeks and 3 months after surgery were （9.40±1.21） s, （4.88±1.90） s and （7.79±1.22） s,the difference was statistically significant （ t1= 12.37,5.78 ;P1〈0.05 ） after 1 weeks and 3 months after surgery. In the control group, 3 d before surgery, 1 W and 3 months after operation, the average value of Sit was （11.02±0.87） ram, （1.11±8.52） mm and （10.14±0.95） mm. 1 weeks after surgery and 3 months after surgery, the difference was statistically significant （ t2 = 11.49,4.42 ; P2 〈0. 05 ）. In the control group, the average value of BUT of 3 d before surgery, 1 weeks and 3 months after surgery was

关 键 词：糖尿病 超声乳化白内障吸除术 基础泪液分泌试验 泪膜破裂时间 

分 类 号：R779.6[医药卫生—眼科] R587.2[医药卫生—临床医学]