腮腺肿瘤患者唾液CEA及CA125的ROC分析  

ROC analysis of CEA and CA125 in saliva of patients with parotid tumor

作　　者：张凯宇[1] 李钧[2] 刘长营[2] 华琳[3] 

机构地区：[1]首都医科大学口腔医学院颌面外科,北京100050 [2]首都医科大学口腔医学院种植中心,北京100050 [3]首都医科大学统计学教研室

出　　处：《北京口腔医学》2015年第6期329-332,共4页Beijing Journal of Stomatology

基　　金：首都临床特色应用研究(北京市科学技术委员会Z111107058811040)

摘　　要：目的通过ROC分析方法,观察并对比唾液样本及血液样本的CA125及CEA水平变化对腮腺肿瘤的临床诊断效能。方法检测正常对照组(30例)和腮腺肿瘤患者(101例)的腮腺液、混合唾液及血液的CA125及CEA水平,通过ROC分析,观察两种标志物单独及联合应用时,诊断腮腺肿瘤的敏感度(SE)、特异度(SP)、AUC值及界值(cutoff)。结果 ROC分析结果显示,混合唾液CA125及CEA对腮腺肿瘤的诊断效能最高(AUC分别为80.4%,78.4%),二者独立应用的诊断效能与联合应用无显著差异。腮腺液及血液样本CA125及CEA的诊断效能处于较低水平(AUC<65%)。结论混合唾液样本CA125与CEA水平的变化可以较好地反映腮腺肿瘤的存在,其临床效能优于腮腺液及血液样本。Objective To evaluate the diagnostic efficiency of saliva （including parotid and whole saliva） and serum CEA and CA125 in patients with parotid tumor. Methods A total of 101 patients with unilateral parotid tumor and 30 healthy people were included in this study. The level of CEA and CA125 in parotid saliva, whole saliva and serum of patients and controls was detected. ROC analysis was conducted to investigate the appropriate AUC, cutoff value, sensitivity and specificity for each biomarker and the combination of two biomarkers. Results The results of ROC analysis showed that the best efficiency to diagnose parotid tumor was found in whole saliva CA125 and CEA, while the efficiency of parotid saliva and serum was relatively low. There was no significant difference in whole saliva CA125 and CEA between single and combined analysis. Conclusion The elevated levels of CEA and CA125 in whole saliva could reflect the occurrence of parotid tumor efficiently.

关 键 词：腮腺肿瘤 CA125 CEA 唾液 血液 ROC分析 

分 类 号：R739.8[医药卫生—肿瘤]