关于引起药物源性角结膜炎常见原发疾病的回顾性分析（英文）  

Retrospective analysis of common primary disease of drug-induced keratoconjunctivitis

作　　者：朱小敏[1] 荣蓓[1] 乔静[1] 晏晓明[1] 

机构地区：[1]北京大学第一医院眼科,视觉损伤与修复教育部重点实验室,100034

出　　处：《国际眼科杂志》2016年第1期7-10,共4页International Eye Science

摘　　要：目的:分析药物源性角结膜炎最常见的原发疾病。方法:对确诊为药物源性角结膜炎的18例患者的病历资料进行回顾性分析,观察药物源性角结膜炎的原发疾病、用药种类、药物使用频率、临床特征、治疗方法、上皮愈合时间和患者的非矫正视力(UCVA)。使用SPSS 18.0统计学软件进行分析,以P<0.05为差异有统计学意义。结果:药物源性角结膜炎的常见原发疾病包括青光眼(6例)、单纯疱疹病毒性角膜炎(6例,其中2例为白内障术后)、带状疱疹病毒性角膜炎(1例)、角膜异物剔除后角膜炎(1例)和无明确病因角膜炎/角膜溃疡(4例)。患者的用药种类为3.3±1.5种,用药频率是9±3.9次/d。16例患者出现角膜病变,而仅有3例患者出现结膜病变(其中1例患者同时出现角膜和结膜病变)。患者的治疗方案包括停用原有药物局部使用不含防腐剂的人工泪液或自体血清,以及低剂量类固醇眼药水。在治疗周期7±2.8d后,患者症状开始缓解。患者上皮愈合周期是21±8.8d。治疗前后患者的UCVA分别是0.15±0.13和0.43±0.27(P=0.003)。结论:病毒性角膜炎和青光眼是药物源性角结膜炎的最常见原发疾病。AIM： To find out the most common primary diseases of drug-induced keratoconjunctivitis. METHODS： The clinical records of 18 patients with a confirmed diagnosis of drug-induced keratoconjunctivitis were retrospectively reviewed. Primary diseases, categories of induced-drugs, numbers of daily drops, characteristics of keratoconjunctivitis, treatment, epithelization period, and un-corrected visual acuity（UCVA）were studied. Data were analyzed by SPSS 18.0. P〈0.05 were considered statistically significant. RESULTS： Primary diseases included glaucoma（n=6）, herpes simplex keratitis（n=6; two patients were post-surgery of cataract）, herpes zoster keratitis（n=1）, keratitis after corneal foreign body taken（n=1）and keratitis/corneal ulcer with unknown etiology（n=4）. Mean number of drugs was 3.3±1.5 and the frequency was 9±3.9 times a day. Keratopathy was found in 16 cases, while conjunctival changes were found only in 3 cases（One patient got corneal and conjunctival changes simultaneously）. Withdrawing the drugs, preservative-free lubricants or autologous serum, and topical low dose steroid drops were used for treatment. After a mean period of 7±2.8d, symptoms began to relieve. The mean epithelization period was 21±8.8d. Mean pretreatment and post-treatment UCVA was 0.15±0.13 and 0.43±0.27, respectively（P=0.003）. CONCLUSION： Viral keratitis and glaucoma are the most often events of drug-induced keratoconjunctivitis.

关 键 词：角结膜炎 药物毒性 原发疾病 青光眼 病毒性角膜炎 

分 类 号：R77[医药卫生—眼科]