六味地黄丸配合牙周基础治疗对绝经期牙周炎患者龈沟中白细胞介素-6、雌二醇的影响  

The effects of Liuwei Dihuang Pill to interleukin-6 and estrogen in gingival crevicular fluid before and after treatment of periodontal during the postmenopausal women

作　　者：任强[1] 李春年[2] 杨冬茹[2] 

机构地区：[1]内蒙古科技大学包头医学院·第一附属医院口腔科,包头014010 [2]河北医科大学口腔医学院·口腔医院口腔内科,河北省口腔医学重点实验室,石家庄050017

出　　处：《国际口腔医学杂志》2016年第1期18-21,共4页International Journal of Stomatology

摘　　要：目的探讨六味地黄丸在绝经期牙周炎患者牙周治疗中的作用。方法选取诊断为中、重度慢性牙周炎且处于绝经期的女性患者27名,分为基础治疗组(12名)和辅助六味地黄丸组(15名),测量治疗前、后龈沟液中白细胞介素(IL)-6及雌二醇(E_2)的浓度。结果治疗后2个月,两组IL-6浓度与治疗前相比均明显降低(P<0.01),但两组间的差异无统计学意义(P>0.05)。E_2浓度较治疗前均有增高,但基础治疗组与治疗前的差异无统计学意义(P>0.05),辅助六味地黄丸组的差异则有统计学意义(P<0.01)。结论牙周基础治疗可显著降低龈沟液中IL-6浓度,改善牙周炎症状态。辅助口服六味地黄丸可提高龈沟液中E_2浓度,有效改善牙周组织局部雌激素水平。Objective To investigate the influence of Liuwei Dihuang PilI（LWDHP） treating periodontal during the postmenopausal women. Methods Twenty-seven postmenopausal female patients with moderate to advanced chronic periodontal disease were chosen, and were divided into two groups randomly. Basic treatment group： patients didn＇t take any medicine, only accept initial therapy of periodontal. LWDHP treatment group： initial therapy of periodontal with oral took LWDHP 2 months. Collected and detected the concentration of interleukin（IL）-6, estrogen（E2） in gingival crevicular fluid（GCF） before and after treatment. Results A significant decrease was shown in the concentrations of GCF-IL-6 of two groups after therapy compared to before treatment on 2nd month, it had statistically differences（P〈0.01）, there were no statistically significant differences between the two groups（P〉0.05）. Basic treatment group increased the concentrations of GCF-E2 of two groups after therapy compared to before treatment on 2nd month. Basic treatment group had no statistically significant difference（P〉0.05）, LWDHP treatment group had statistically significant differences（P〈0.01）. Conclusion Periodontal initial therapy can make the concentration of IL-6 in GCF decrease and improves periodontal condition. The concentration of E2 in GCF could be increased by LWDHP.

关 键 词：牙周炎 六味地黄丸 雌激素 白细胞介素-6 

分 类 号：R781.42[医药卫生—口腔医学]