长链非编码RNA在牙周炎和口腔肿瘤疾病中的作用  

Role of long noncoding RNA in periodontal disease and oral cancer

作　　者：屈茜[1] 房付春[1] 吴补领[1,2] 

机构地区：[1]南方医科大学口腔医学院 [2]南方医科大学南方医院口腔科,广州510515

出　　处：《国际口腔医学杂志》2016年第1期62-65,共4页International Journal of Stomatology

基　　金：广东省自然科学基金(2015A030310140);南方医科大学南方医院院长基金(2014B005)~~

摘　　要：长链非编码RNA(lncRNA)是一类内源性的长度大于200个核苷酸、缺少特异完整的开放阅读框,不具有或很少具有蛋白质编码功能的转录本,一度被认为是基因组转录中的噪音,没有生物学功能;而近来的研究显示,lncRNA可通过介导染色质重塑、组蛋白修饰、X染色体失活以及基因组印迹、转录、剪接、翻译、降解和转运等途径,在表观遗传水平、转录水平和转录后水平等层面上调控基因的表达,从而影响疾病的发生发展。在口腔疾病中,lncRNA与牙周炎、口腔癌前病变和口腔颌面部肿瘤等关系密切。超过60%的在癌组织中异常表达的lncRNA皆在口腔癌前病变组织中有异常表达,所以lncRNA不仅可以作为牙周炎、口腔癌前病变和口腔颌面部肿瘤诊断的潜在标志物,还可为临床预后的判断及治疗方案的确定提供指导。Long noncoding RNA（lncRNA） are a group of endogenous transcripts that are longer than 200 nucleotides, lack a specific complete open reading frame, and have no or limited protein-coding capacity. IncRNA are considered transcriptional ＂noise＂ because of their lack of biological functions. However, recent studies have revealed that lncRNA participate in genome organization and in life processes such as the growth and development, proliferation, differentiation, and apoptosis of cells. Furthermore, lncRNA have been closely associated with the development of numerous diseases and are becoming the new direction of genome research. Previous research found that lncRNA are related to periodontal disease, oral premalignant lesions, and oral cancer. Over 60% of differently expressed lncRNA in cancer tissue can be found in oral cancer tissue. Therefore, lncRNA can be a biomarker and provide guidance for the clinical cure and prognosis of periodontal disease, oral premalignant lesion, and oral cancer.

关 键 词：长链非编码RNA 牙周炎 口腔癌前病变 口腔颌面肿瘤 

分 类 号：R781.42[医药卫生—口腔医学] R739.8[医药卫生—临床医学]