异基因造血干细胞移植联合供者源淋巴细胞及EBV特异性杀伤T细胞治疗种痘水疱样淋巴瘤一例报告及文献复习  

Allogeneic hematopoietic stem cell transplantation followed by donor derived lymphocyte and EBV specif- ic cytotoxic T -lymphocyte immunotherapy for hydroa vacciniforme -like lymphoma：A case report and literature review

作　　者：徐数娜[1] 刘丽辉[1] 张永清[1] 胡文青[1] 

机构地区：[1]解放军第309医院,北京100094

出　　处：《实用肿瘤学杂志》2015年第6期533-535,共3页Practical Oncology Journal

摘　　要：种痘水疱样淋巴瘤临床表现为疱疹，伴有发热、肝脾肿大、淋巴结肿大等系统症状。病理示真皮内淋巴细胞浸润，可见部分异形细胞，免疫组化示Bcl-6、Bcl-2、CD3、CD8、TIA、CD4、granzyme和EBER均阳性，而CD56、CD20均阴性。骨髓细胞TCR重排阳性。种痘水疱样淋巴瘤较罕见，临床易误诊。传统治疗效果差，异基因造血干细胞移植联合回输淋巴细胞及EBV特异性杀伤T细胞治疗种痘水疱样淋巴瘤的疗效好，可能是根治HVLL的有效手段。The hydroa vacciniforme - like lymphoma is clinically manifested by rash, fever, hepatospleno- megaly and lymphadenectasis. Pathological character showed that lymphocytes infiltrated into dermis and there were some heterocysts. Immunohistoehemistory showed that Bcl - 6, Bcl - 2, CD3, CD8, TIA, CIM, granzyme, EBER were positive, CD56, CD20 all tested negative. The rearrangement of TCR of bone marrow cell was positive. The hydroa vacciniforme - like lymphoma is uncommon clinically, and it is easy to misdiagnosed. The effect of tra- ditional therapy is poor, while the allogeneie hematopoietic stem cell transplantation followed by lymphocyte and donor - derived EBV - specific eytotoxic T - lymphocyte immunotherapy is effective, which may offer an curable therapy for HVLL.

关 键 词：种痘水疱样淋巴瘤 造血干细胞移植 EBV特异性杀伤T细胞 

分 类 号：R733.4[医药卫生—肿瘤]