慢性应激抑郁模型的感觉和动力评价  

Evaluation of visceral sensation and motility in chronic unpredictable mild stress animal model

作　　者：吕红[1] 钱家鸣[1] 金光亮[2] 周东丰[3] 沈渔邨[3] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院消化科,北京100730 [2]北京中医药大学,北京100000 [3]北京大学第6医院,北京100000

出　　处：《临床消化病杂志》2015年第6期323-326,共4页Chinese Journal of Clinical Gastroenterology

基　　金：国家自然科学基金资助项目(No:30470795)

摘　　要：[目的]对大鼠慢性轻度不可预见性的应激(CUMS)模型进行胃肠感觉和动力等方面的评估。[方法]将模型大鼠分为CUMS组和对照组,分别于实验前后检测2组大鼠动力(排便颗粒、排便时间)、感觉(自发性腹外斜肌收缩)和行为/心理(糖水摄取量、体质量)等指标改变。[结果]1CUMS组大鼠实验后出现糖水摄取量明显下降、体质量增长缓慢现象,与对照组比较均差异有统计学意义(P<0.01);2气囊容量在0.8 ml和1.2 ml时,CUMS组腹部收缩次数增加,与对照组比较均差异有统计学意义(P<0.01);3CUMS组大鼠的直肠传输时间与对照组无明显差别(P>0.05)。[结论]CUMS抑郁模型可作为研究心理行为障碍与内脏感觉异常相关性机制的平台,尤其针对那些胃肠动力无明显改变者。[Objective]To evaluate the changes of visceral sensation and motility in chronic unpredictable mild stress（CUMS）animal model. [Methods]The animals were divided into two groups,CUMS and control. Changes of Such indexes were recorded including motility（granules of defecating, time of defecating）, visceral sensitivity（spontaneous contraction of abdominal striated muscles）and behavior/mind（sucrose consumption, body weight）before and after the CUMS. [Results]①The sucrose consumption decreased significantly and the body weight increased slowly at the end of the third week in CUMS compared with the control group（P〈0.01）. ②Comparing with the control group, the numbers of abdominal contraction were increased in CUMS when balloon volume were at 0.8 ml and 1.2 ml respectively（P〈0.01）. ③ No significant change was found on defecating behavior in CUMS（P〉0.05）. [Conclusion]CUMS depression model can be used as a research platform for patients with mental disorders and visceral hypertension, especially for those without motility disorders.

关 键 词：慢性轻度不可预见性应激 动物模型 内脏感觉 抑郁 

分 类 号：R749.5[医药卫生—神经病学与精神病学] R-332[医药卫生—临床医学]