含铋剂的四联疗法与标准三联疗法对幽门螺杆菌相关性消化性溃疡的疗效对比  

Comparative study of the effects of bismuth-containing quadruple and triple chemotherapy for the treatment with peptic ulcer disease

作　　者：李锐强[1] 胡宝英[1] 

机构地区：[1]南方医科大学附属小榄医院消化内科,广东中山528415

出　　处：《临床消化病杂志》2015年第6期327-329,共3页Chinese Journal of Clinical Gastroenterology

摘　　要：[目的]比较标准三联疗法与含铋剂的四联疗法对幽门螺杆菌(Hp)相关性消化性溃疡(PU)的疗效。[方法]入选经胃镜检查确诊的48例Hp相关性PU患者,随机分为对照组和治疗组,2组均为24例。对照组采用传统的标准三联疗法,即给服奥美拉唑、阿莫西林、克拉霉素,2次/d;治疗组在对照组治疗的基础上加服枸橼酸铋钾胶囊,2次/d;2组疗程均为2周。4周后对患者进行胃镜检查并测Hp,对患者疼痛的缓解、Hp转阴、溃疡的愈合及不良反应情况进行分析。[结果]治疗组、对照组溃疡愈合率分别为91.67%、70.83%,治疗组、对照组Hp根除率分别为83.33%、54.17%;2组溃疡愈合率、Hp根除率比较均差异有统计学意义(P<0.05)。但2组在患者疼痛的缓解和不良反应方面比较差异无统计学意义(P>0.05)。[结论]含铋剂的四联疗法经济安全,且疗效显着高于三联疗法,值得在临床上大力推广。[Objective]To compare the effects of the traditional standard triple therapy and quadruple therapy containing bismuth on the treatment of peptic ulcer（PU）disease. [Methods]During March 2013 to May 2014,48 cases of PU patients diagnosed by endoscopy in our hospital were randomly divided into control and treatment groups with 24 cases in each groups. The cases in control group were treated with tradi- tional standard triple therapy （omeprazole, amoxicillin, clarithromycin, 2 times/d, 2 weeks）. The cases in treatment group were treated with and additional bismuth on the base of standard triple therapy. The pain relief, Hp eradication, ulcer healing and adverse reactions 4 weeks after the treatment were compared. [Results]In the treatment groups, the ulcers healing rate was 91.67%,which was higher than the control group （70.83%）. The Hp eradication rate in the treatment group were 83.33% ,which was higher than the control group（54.17%）. The difference in pain relief and adverse reactions between the both groups were not significant（P〉 0.05）. [Conclusion]Quadruple therapy containing bismuth has higher effect on ulcer healing and Hp eradication than triple therapy with similar safety. It is worthy of clinically promoting.

关 键 词：消化性溃疡 铋剂 四联疗法 三联疗法 

分 类 号：R573.1[医药卫生—消化系统]