肿瘤标志物的联合检测在肺癌诊断中的价值  

The value of joint detection of tumor markers in the clinical diagnosis of lung cancer

作　　者：王刚[1] 张茜[1] 张延京[1] 

机构地区：[1]首都医科大学附属北京友谊医院检验科,北京100050

出　　处：《中华实验和临床病毒学杂志》2015年第6期537-539,共3页Chinese Journal of Experimental and Clinical Virology

摘　　要：目的探讨血清肿瘤标志物神经特异性烯醇化酶（NSE）、细胞角蛋白21—1片段（CYFRA21-1）、糖类抗原125（CA125）、癌胚抗原（CEA）、肿瘤相关物质（TSGF）和鳞状细胞抗原（SCC）在肺癌诊断中的价值。方法采用免疫化学发光法分别检测76例肺癌患者、50例肺良性疾病患者和48例健康对照组血清中的6种肿瘤标志物含量。结果肺癌患者6种标志物血清浓度明显高于健康对照组（P〈0．05）；除CA125外，其他5种含量均明显高于肺良性疾患组（P〈0．05）。SCC和CYFRA21-1浓度在肺鳞癌组中明显高于其他两个组肺癌（P〈0．05和P〈0．01），CA125和CEA浓度在肺腺癌组中明显高于其他两组肺癌（均P〈0．01），NSE浓度在小细胞肺癌组中高于其他两组肺癌（P〈0．05），TSGF在三组肺癌中浓度无明显差异（P〉0．05）。联合检测可明显提高肺癌诊断的敏感性（P〈0．01）。结论联合检测肿瘤标志物在肺癌诊断及肺癌病理分型中具有较高的临床应用价值，优于单项检测。Objective To investigate the value of detection of 6 tumor markers： neuronspecific enolase （ NSE ） , eytokeratin fragment 21-1 （ CYFRA21-1 ） , carbohydrate antigen 125 （ CA125 ） , carcinoembryonic antigen （CEA）, Tumor Specific Growth Factor （TSGF） and squamous cell carcinoma antigen（SCC） in the clinical diagnosis of lung cancer. Methods From July 2013 to July 2014, 174 blood samples were collected from 76 lung cancer patients ,50 lung benign disease patients and 48 healthy controls. All the blood sample were detected for 6 tumor markers mentioned above by Immune chemiluminescence technique. Results Lung cancer patients have higher levels of 6 tumor markers than healthy controls（P 〈 0. 005 ） and have higher levels of 5 tumor markers except CA125 than patients with benign lung diseases（ P 〈 0.05）. Among lung cancer patients, levels of 6 tumor markers were compared by 3 types of lung cancer as lung squamous cell carcinoma, lung adenocarcinoma and small cell carcinoma. Patients with lung squamous cell carcinoma have higher levels of SCC and CYFRA21-1 than patients with other two types（P 〈 0. 05 ,P 〈0. 01 ）. Patients with lung adenocareinoma have higher levels of CA125 and CEA than patients with other two types （ both P 〈 0. 01 ）. Patients with small cell carcinoma had the highest level of NSE（ P 〈 0. 05）. No significant differences of TSGF level were observed among the 3 types of lung cancer. Conclusion The combined detection of multiple tumor markers is very useful in the diagnosis of lung cancer and in the pathologic classification and better than single assay.

关 键 词：肺癌 肿瘤标志物 

分 类 号：R734.2[医药卫生—肿瘤]