术前NLR PLR与乳腺癌预后的相关性  

Correlation of preoperative neutrophil to lymphocyte ratio and platelet to lymphocyte ratio with prognosis of breast cancer

作　　者：朴美慈[1] 金仁顺[1] 

机构地区：[1]延边大学附属医院病理科,吉林省延吉市133000

出　　处：《中国肿瘤临床》2015年第23期1128-1131,共4页Chinese Journal of Clinical Oncology

摘　　要：目的:研究外周血中中性粒细胞和淋巴细胞绝对值的比值(neutrophil to lymphocyte ratio,NLR)、血小板和淋巴细胞绝对值的比值(platelet to lymphocyteratio ratio,PLR)与乳腺癌预后的相关性。方法:收集2011年1月至2014年12月延边大学附属医院316例行乳腺癌根治术患者的临床病理资料,分析NLR、PLR与乳腺癌TNM分期、雌激素受体、HER-2及三阴性乳腺癌之间的关系。结果:NLR与乳腺癌TNM分期之间有相关性(P<0.05)、与乳腺癌雌激素受体、HER-2及三阴性乳腺癌之间无相关性(P>0.05),PLR与乳腺癌TNM分期及雌激素受体、HER-2及三阴性乳腺癌之间均无相关性(P>0.05)。结论:术前NLR水平作为全身炎症反应的指标可有效预测乳腺癌的预后。Objective： To assess neutrophil to lymphocyte ratio （NLR） and platelet to lymphocyte ratio （PLR） in peripheral blood of breast cancer patients and to investigate their correlation with patient prognosis. Methods： Clinical data of 316 patients with breast cancer, who underwent radical mastectomy between December 2014 and January 2011 in The Affiliated Hospital of Yanbian University were collected. Clinical and pathological data including NLR, PLR, TNM staging, ER, HER-2 and triple-negative breast cancer were analyzed. Results： There was a significant correlation （P〈0.05） between NLR and TNM staging in breast cancer. There was no significant correlation among NLR and the values of estrogen receptor （ER）, HER-2 and triple negative breast cancer （P〉0.05）. Also, there was no significant correlation among PLR and TNM staging, and the values of ER, HER-2 and triple-negative breast cancer （P〉0.05）. Conclusion： NLR level before treatment, as an indicator of systemic inflammation, can effectively predict the prognosis of breast cancer.

关 键 词：乳腺癌 预后 NLR PLR 

分 类 号：R737.9[医药卫生—肿瘤]