焦虑和抑郁症状与老年认知功能障碍的相关性研究  

The Association between Anxiety and Depression Symptoms and Cognitive Impairment in Elderly

作　　者：梁小妞 丁玎[4] 罗剑锋[1,2,3] 赵倩华[4] 郭起浩[4] 周燕[4] 俞丽蓉[4] 郑琍 洪震[4] 

机构地区：[1]复旦大学公共卫生学院生物统计教研室 [2]公共卫生安全教育部重点实验室 [3]卫生部卫生技术评估重点实验室,200032 [4]复旦大学附属华山医院神经内科,200040

出　　处：《中国临床神经科学》2015年第6期635-641,共7页Chinese Journal of Clinical Neurosciences

基　　金：复旦大学自主科研项目(编号:20520133106)

摘　　要：目的调查研究社区／〉50岁老年人认知功能障碍与焦虑、抑郁症状的关系。方法采用横断面调查，对I〉50岁的社区居民进行全套神经系统体检、神经心理测试，根据国际统一的诊断标准诊断痴呆和轻度认知功能障碍（MCI）。采用LogisticIN归模型分析焦虑、抑郁症状与痴呆和MCI的相关性。结果完成全部测试项目的3738名研究对象中，155例（4．1％）被诊断为痴呆（痴呆组），691例（18．5％）被诊断为MCI（MCI组）。2892名（77．4％）无痴呆和MCI的研究对象为认知功能正常（正常组）。经多因素分析校正多个变量后发现，男性患者抑郁症状得分每增3hi分，患痴呆相对正常组患病率增高6．2％（O暇=1．062，95％CI：1．020-1．105），预测概率范围为（0．01，0．10）；女性患者抑郁症状得分每增加1分，患痴呆或MCl4相对对正常组患病率增高4．6％（OR=1．046，95％CI：1．013-1．079）、3．2％（OR=1．032，95％CI：1．017-1．047），预测概率范围分别为（0．01，0．10）、（0．12，0．36），焦虑症状得分每增加1分，患MCI相对正常组患病率增高2．2％（OR=1．022，95％CI：1．005-1．040），预测概率范围为（0．10，0．28）。结论横断面调查发现痴呆与越高的抑郁症状得分有关；在女性中，MCI与越高的焦虑、抑郁症状得分有关；在男性中则无这种关系存在。Aim To investigate the correlation between anxiety and depression symptoms and dementia as well as mild cognitive impairment （MCI） of elderly aged fifty or older in a community. Methods A cross- sectional study was used. Residents with 50 years or older were interviewed with neurological examination and neuropsychological tests. Diagnosis of dementia and MCI was made based on the international diagnostic criteria. Logistic regression was used to analyze the association between anxiety and depression symptoms and dementia or MCI. Results For the 3 738 cases, 155 （4.1%） cases were diagnosed with dementia and 691 （18.5%） cases were diagnosed with MCI. In the multivariate Logistic regression model adjusting multiple variables, for men, higher CESD scores （every one point increase） was a risk factor of dementia （OR=1.062, 95%CI： 1.020-1.105） and its predicted probability for dementia was （0.01, 0.10）. For women, higher CESD scores （every one point increase） was a risk factor of dementia （OR=1.046, 95%CI： 1.013-1.079） and MCI （OR=1.032, 95%CI： 1.017-1.047）, and its predicted probability for dementia or MCI was （0.01, 0.10） or （0.12, 0.36）, respectively; higher ZSAS scores （every one point increase） was a risk factor of MCI （OR=1.022, 95%CI： 1.005-1.040） and its predicted probability for dementia was （0.10, 0.28）. Conclusion The cross-sectional study found that dementia was associated with higher CESD scores, for Conclusion The cross-sectional study found that dementia was associated with higher CESD scores, for women gender not men gender, MCI was associated with higher ZSAS and CESD scores.

关 键 词：焦虑症状 抑郁症状 轻度认知功能障碍 痴呆 老年 横断面调查 

分 类 号：R749[医药卫生—神经病学与精神病学]