肿瘤坏死因子超家族成员4基因SNP rs505922与滕州地区动脉粥样硬化性脑梗死发病的关系  

Relationship of Tumor Necrosis Factor Super Family Member 4(TNFSF4) Gene SNP rs505922 with Atherosclerotic Cerebral Infarction in Tengzhou Region

作　　者：宋正锋[1,2] 耿德勤[1] 许艳[3] 戚鹏[2] 

机构地区：[1]徐州医学院研究生院,221004 [2]山东省滕州市中心人民医院神经内科,277599 [3]徐州医学院附属医院神经内科,221002

出　　处：《中国临床神经科学》2015年第6期642-646,656,共6页Chinese Journal of Clinical Neurosciences

基　　金：徐州市科技发展计划(编号:KC14SX016)

摘　　要：目的探讨肿瘤坏死因子超家族成员4(TNFSF4)基因rs505922位点单核苷酸多态性(SNP)与动脉粥样硬化性脑梗死发病的关系。方法选取2012年1月至2013年12月收治的185例山东省滕州市户籍的动脉粥样硬化性脑梗死患者为缺血性脑卒中组,另选取180名行常规检查的正常体检者为对照组。采用PCR-RFLP法测定两组TNFSF4基因上SNP rs505922的基因频率及多态性。结果 rs505922基因型及基因频率分析表明缺血性脑卒中组C等位基因频率高于对照组,差异有统计学意义(P<0.05)。经Logistic多因素分析可知rs505922 CC型是动脉粥样硬化性脑梗死发病风险的独立危险因子。结论 TNFSF4基因位点上SNP rs505922 CC型与滕州地区动脉粥样硬化性脑梗死关系密切。Aim To investigate the relationship between the lnClclence of atneroscLerouc cereoral infarction and tumor necrosis factor super family member 4 （TNFSF4） on the upper point of the gene and the gene frequency single nucleotide polymorphism （SNP） rs505922 polymorphism. Methods 185 patients with atherosclerotic cerebral infarction in local household registration hospital from January 2012 to 12 January 2013 were selected. The other 180 cases for routine checks in our hospital were selected as a control group. The polymorphism and gene frequencies of SNP rs505922 on TNFSF4 were detected by polymerase chain reaction assay. Results The analysis of rs505922 genotype and allele frequency showed that C allele frequency in atherosclerofic cerebral infarction group was higher than that in the control group, the difference was statistically significant （P〈0.05）. CC genotype was an independent risk of atherosclerotic cerebral infarction risk factors. Conclusion The upper point TNFSF4 gene on SNP rs505922 CC genotype was closely related with local atherosclerotic cerebral infarction.

关 键 词：动脉粥样硬化性脑梗死 肿瘤坏死因子超家族成员4 单核苷酸多态性 rs505922基因位点 

分 类 号：R743[医药卫生—神经病学与精神病学]