47例单中心乳腺叶状肿瘤的病理与临床分析  

Pathological and clinical features of 47 cases of breast phyllodes tumor

作　　者：田杰[1] 周东华[1] 平静[1] 葛娟[1] 刘小燕[1] 陈莹[1] 范菊花[1] 

机构地区：[1]南方医科大学附属佛山市妇幼保健院病理科,广东佛山528000

出　　处：《临床与病理杂志》2015年第12期2078-2082,共5页Journal of Clinical and Pathological Research

摘　　要：目的:总结分析乳腺叶状肿瘤的病理与临床的特点,为乳腺叶状肿瘤的诊治提供依据。方法:对2009年1月至2015年6月期间在我院经手术切除诊断为叶状肿瘤的47例病例的病理及临床特点进行总结分析。结果:47例患者均为女性,术后病理诊断良性叶状肿瘤40例,交界性叶状肿瘤4例,恶性叶状肿瘤3例。免疫组化发现在良性、交界性、恶性叶状肿瘤中S-100、Vimentin表达无差别,SMA、CD117、CD34、CD10、P53随着恶性度增加,阳性率增加,但是表达差异无显著性,Ki67增殖指数差异显著(P<0.05)。在随访过程中,3例行单纯肿物切除的良性病例复发。结论:乳腺叶状肿瘤以良性病变较多见,免疫组化可协助病理的鉴别诊断。单纯肿物切除的病例复发机率高。采用适当的手术方式,可能降低复发率。Objective： To analyze the clinical characteristics and pathological features of breast phyllodes tumor. Methods： We retrospectively analyze 47cases of breast phyllodes tumor which diagnosed from January 2009 to June 2015. Results： The 47 patients with phyllodes tumors were all females. In the 47 patients, 40 patients were benign tumors, 4 patients were borderline tumors, and 3 patients were malignant tumors. The expression of S-100 and Vimentin was no difference. With the malignant degree increased, the positive rate of SMA, CD117, CD34, CD10 and pS3 increased, but there was no significant difference. The Ki67 proliferation index was significantly difference （P〈0.05） between three groups. A total of 42 cases were followed-up, 3 cases with benign tumor which only underwent local excision of the masses recured. Conclusion： Most of phyUodes tumors are benign. Immunohistochemical can improve the differential pathological diagnosis; the recurrence risk of which only underwent local excision of the masse is high. So using appropriate surgical procedure may reduce the recurrence rate.

关 键 词：乳腺 叶状肿瘤 病理与临床特征 

分 类 号：R737.9[医药卫生—肿瘤]