成人癫痫患者抑郁状况及其生态学执行功能特点  

Depressive state and features of ecological executive function in adults with epilepsy

作　　者：刘天龙[1] 刘维洲[1] 周农[2] 

机构地区：[1]铜陵市人民医院神经内科,安徽省铜陵市244009 [2]安徽医科大学第一附属医院神经内科,安徽省合肥市230022

出　　处：《国际神经病学神经外科学杂志》2015年第5期432-435,共4页Journal of International Neurology and Neurosurgery

基　　金：安徽省教育厅自然基金重点项目(KJ2012A175)

摘　　要：目的探讨成人癫痫患者抑郁状况及其生态学执行功能特点。方法应用汉密尔顿抑郁量表(HAMD)和执行功能行为评定量表成人自评问卷(BRIEF-A)对96例成人癫痫患者和54例性别、年龄、受教育程度等与之匹配的正常成人进行抑郁和生态学执行功能评定。结果癫痫患者抑郁障碍发生率明显高于正常对照组,差异有统计学意义(P<0.01)。回归分析显示,经济收入、癫痫控制情况与癫痫伴发抑郁障碍显著相关(P<0.01)。癫痫抑郁组和非抑郁组BRIEF-A总分及各因子得分均明显高于对照组,差异有统计学意义(P<0.01);抑郁组除抑制、感情控制和组织3个因子外其它各因子得分均明显高于非抑郁组,差异有统计学意义(P<0.05)。结论成人癫痫患者抑郁发生率高,伴发抑郁的癫痫患者生态学执行功能障碍更明显,临床上应重视癫痫合并抑郁的诊断和治疗。Objective To investigate the depressive state and the features of ecological executive function in adults with epilepsy. Methods Depressive state and ecological executive function were assessed in 96 adults with epilepsy and 54 normal ones with matched sex, age, and educational level, with the application of Hamilton Depression Scale and Behavior Rating Inventory of Executive Func- tion-Adult Version （BRIEF-A）. Results The patients with epilepsy had a significantly higher incidence rate of depressive disorder than those in the normal control group （P 〈 0.01 ）. Multiple stepwise linear regression analysis showed that economic income and dis- ease control were closely related to the incidence of epilepsy complicated by depressive disorder （ P 〈 0.01 ）. The epilepsy-depression group and epilepsy-non-depression group had significantly higher BRIEF-A total score and scores on all BRIEF-A subscales than the control group （P 〈 0.01 ） ; compared with the epilepsy-non-depression group, the epilepsy-depression group had significantly higher BRIEF-A subscale scores except those on Inhibit, Emotional Control, and Plan/Organize subscales （P 〈 0. 05）. Conclusions The a- dults with epilepsy have a high incidence rate of depression, and those with depression have obvious disorders of ecological executive function. The diagnosis and treatment of epilepsy with depression should be emphasized in clinical practice.

关 键 词：癫痫 抑郁 生态学 执行功能 

分 类 号：R742.1[医药卫生—神经病学与精神病学]