血浆D-D，FDP及血清hs-CRP检测对多发性腔隙性脑梗死的临床意义  

Clinical Study on Plasma D-D,FDP and Sera hs-CRP Test for Multipleh Lacunar Infarction

作　　者：施瑞洁[1] 刘文康[1] 李博[1] 陈红男 王俊燕[2] 白小渭[1] 李玲[1] 

机构地区：[1]陕西省人民医院检验科,西安710068 [2]唐都医院,西安710038

出　　处：《现代检验医学杂志》2015年第6期75-77,共3页Journal of Modern Laboratory Medicine

摘　　要：目的通过对多发性腔隙性脑梗死患者血浆D-二聚体（D-D），纤维蛋白原降解产物（FDP）及血清超敏C反应蛋白（hs—CRP）浓度水平的检测，探讨三项指标与多发性腔隙性脑梗死发病的相关性。方法选择健康体检者40例，经临床确诊为多发性腔隙性脑梗死患者88例，采用SYSMEx全自动凝血分析仪分别检测其血浆D-D，FDP及血清hs-CRP浓度水平。结果多发性腔隙性脑梗死组D-D，FDP，hs—CRP检测结果分别为：0．95±1．24rag／L,3.33±11．49mg／L和8．65土20．39g／L；健康体检组D-D，FDP和hs—CRP检测结果分别为：0．32±0．37mg／L，0．047±0．16mg／L和0．87±0．78g／L。经统计学分析，t值分别为6．7，12．4和8．7，其P值均〈0．05，两组之间D-D，FDP和hs-CRP三项指标差异有统计学意义。同时发现DD检测结果患者组高于正常参考范围的阳性率，高于FDP的阳性率且P〈0．05，χ^2=22．45，差异有统计学意义。结论血浆DD，FDP及血清hs—CRP检测结果高于正常参考范围时与多发性腔隙性脑梗死发病密切相关，三项指标对多发性腔隙性脑梗死的诊断和治疗监测有非常重要的临床意义。Objective To discuss the relevance between these three indicators and muhipleh lacunar infarction attack,through analyzing concentration level of plasma D-D,FDP and sera hs-CRP of multipleh lacunar infarction patient. Methods Chose 40 cases of healthy controls and 88 cases of clinically confirmed multipleh lacunar infarction patient,and used SYSMEX automatic coagulation analyzer to test their concentration level of plasma D-D,FDP and sera hs-CRP respectively. Results The test results of muhipleh lacunar infarction group were：0.95±1.24 mg/L,3.33±11.49 mg/L,8. 65±20.39 g/L and group of healthy controls were 0.32±0.37 mg/L,0. 047±0.16 mg/L,0. 87±0.78 g/L. After statistical analysis,P values of plasma D-D,FDP and sera hs-CRP of these two groups were less than 0.05 which manifest differences were statistically significant. Meanwhile the D-D test result of the patient group was higher than the normal reference range of positive rate,exceeds the positive rate of FDP and P〈0.05, with statistical significance： Conclusion The test results of plasma D-D,FDP and sera hs-CRP were closely related with muhipleh lacunar infarction attack if these three indicators exceed normal reference range. These three indicators are of great clinical significance on the diagnosis and treatment monitoring of multipleh lacunar infarction.

关 键 词：纤维蛋白原降解产物 D-二聚体 超敏C反应蛋白 多发性腔隙性脑梗死 

分 类 号：R743[医药卫生—神经病学与精神病学] R446.112[医药卫生—临床医学]