广泛性焦虑障碍患者人格特征与血浆皮质醇水平的相关研究  

Association study on personality and plasma cortisol level in the patients with generalized anxiety disorder

作　　者：周田田[1] 孔伶俐[1] 刘春文[2] 

机构地区：[1]青岛市精神卫生中心,青岛266034 [2]青岛大学医学院

出　　处：《中华行为医学与脑科学杂志》2015年第12期1113-1116,共4页Chinese Journal of Behavioral Medicine and Brain Science

摘　　要：目的探讨广泛性焦虑障碍患者人格特征与血浆皮质醇水平的相关性。方法对38例符合美国精神障碍诊断统计手册第四版（DSM—Ⅳ）的广泛性焦虑障碍患者，使用汉密尔顿焦虑量表（HAMA）、广泛性焦虑量表（GAD-7）、宾州忧虑问卷（PSWQ）、症状自评量表（SCL-90）、艾森克人格问卷（EPQ），筛选广泛性焦虑障碍患者、评估其焦虑症状的严重程度、心理健康水平及人格特征，采用电化学发光法检测其血浆皮质醇水平。并设置39例正常对照与之进行对照研究。结果GAD患者EPQ中的N分显著高于正常对照组（t=14．307，P〈0．01），且N分与HAMA总分、SCL-90总分、躯体化、人际关系敏感、抑郁、焦虑均存在显著性正相关（r=0．492—0．977，P〈0．01）。GAD患者的血浆皮质醇浓度[（668．50±60．22）nmol／L]高于正常对照组[（345．35±58．91）nmol／L]，差异有统计学意义（t=23．802，P〈0．01）。血浆皮质醇浓度与N分、GAD-7、PSWQ、HAMA评分、SCL-90总分、躯体化、人际关系敏感、抑郁、焦虑均呈显著性正相关（r=0．501～0．995，P〈0．01）。结论广泛性焦虑障碍患者的血浆皮质醇水平较正常对照组明显增高，其血浆皮质醇水平可能与心理健康水平相关，且多具有神经质倾向的个性特征。Objective To study the correlation of personality characteristics and plasma cortisol levels in the patients with generalized anxiety disorder. Methods According to Diagnostic and Statistieal Manual of Mental Disorders （DSM-Ⅳ）, 38 patients with generalized anxiety disorder and 39 normal controls were assessed with Ham- ilton anxiety scale（ HAMA）, generalized anxiety disorder scale（ GAD-7）, penn state worry questionnaire（ PSWQ）, symptom checklist-90（SCL-90） and eysenck personality questionnaire（EPQ） .Electrochemiluminescence was used to test plasma cortisol concentration. Results The EPQ-N score in the patients was significantly higher than that in normal controls（ t= 14.307, P〈0.01）.Furthermore, N score in the patients showed a significantly positive corre- lation with HAMA total score, SCL-90 total score, somatization score, interpersonal sensitivity score, depression score and anxiety score （ r= 0.492-0.977, P〈0.01）.Plasma cortisol levels in patients with generalized anxiety dis- order（（668.50±60.22） nmol/L） were significantly higher than those （（345.35±58.91）nmol/L） in normal con- trols （ t= 23.802, P〈 0. 01） . Plasma eortisol concentrations displayed a significantly positive correlation with N score, GAD-7, PSWQ, HAMA total score, SCL-90 total score, somatization score, interpersonal sensitivity score, de- pression score,and anxiety score （ r= 0.501-0.995, P〈0.01 ）. Conclusion Plasma eortisol levels in the patients with generalized anxiety disorder are higher than those in normal controls. Plasma cortisol levels are related to the mental health.Patients with generalized anxiety disorder tend to be neuroticism.

关 键 词：广泛性焦虑障碍 人格特征 皮质醇 Pearson相关分析 

分 类 号：R749.7[医药卫生—神经病学与精神病学]