中西医结合治疗脑梗死后血管性痴呆临床疗效的Meta分析  

Efficacy of Integrated Traditional Chinese and Western Medicine Therapy for Vascular Dementia after Cerebral Infarction:A Meta-analysis

作　　者：崔道宁 杨晓波[1] 党晓娟[1] 

机构地区：[1]甘肃中医学院

出　　处：《按摩与康复医学》2015年第23期26-29,共4页Chinese Manipulation and Rehabilitation Medicine

摘　　要：目的：通过Meta分析评价中西医结合治疗脑梗死后血管性痴呆的临床疗效.方法：检索万方数据库、重庆维普数据库、中国知网数据库、Pubmed数据库及手工检索,纳入中西医结合治疗脑梗后血管性痴呆与常规治疗比较的随机对照试验（RCT）和临床对照试验（CCT）,根据改良后Jadad评分标准评价纳入研究文献的质量,采用RevMan5.2统计软件分析.结果：17篇文献符合纳入标准,共计1240例脑梗死后血管性痴呆患者,Meta分析显示中西医结合治疗脑梗死后血管性痴呆总有效率比较具有统计学意义,合并RR（固定效应模型）=1.34,95%可信区间（1.22,1.47）,Z=6.28,P〈0.00001.结论：中西医结合治疗脑梗死后血管性痴呆的总有效率明显优于临床常规疗法,但纳入的CCT和RCT研究较少,部分文献的样本量较小,缺乏多中心随机对照研究,尚需高质量研究进一步验证.Objective：To evaluate the efficacy of integrated traditional Chinese and western medicine therapy for vascular dementia after cerebral in-farction. Methods：We electronically searched Wanfang Medical Data System, Chongqing VIP database, CNKI （China National Knowledge Infra-structure）database, Pubmed Internet Online database and manual searches, included in the randomized controlled trials （RCT） and controlled clinical trials （CCT） of comparison between integrated traditional Chinese and western medicine therapy for vascular dementia after cerebral infarction and traditional therapy. Assessed the quality of study literatures according to the Jadad score ratings. With RevMan5.2 statistical software for analysis. Re-sults：A total number of 17 literatures involving 1240 patients met the inclusion criteria, Meta-analysis showed that the overall effective rate of treat-ment in the group receiving integrated traditional Chinese and western medicine therapy was higher than that in the traditional therapy group, statisti-cal significance can be found between the differences of treatment group and control group [merged RR （fixed effects model）=1.34, 95%confidence interval （1.22,1.47）, Z=6.28, p〈0.00001]. Conclusion：The overall effective rate of integrated traditional Chinese and western medicine therapy for vascular dementia after cerebral infarction treatment for vascular dementia after cerebral infarction was significantly superior to clinical traditional therapy, indicated that its clinical effect is worthy to be defined. However, due to the limited number of CCT and RCT literatures, especially those of large samples and multi-center randomized controlled studies, we couldn＇t come to an affirmative conclusion and evidence of high quality still need to be clarified.

关 键 词：血管性痴呆 脑梗死 中西医结合 META分析 随机对照试验 临床对照试验 疗效 

分 类 号：R749.1[医药卫生—神经病学与精神病学]