正常人眼角膜上皮层厚度的分布及其相关因素  

Distribution and related factors of corneal epithelial thickness in a population with normal eyes

作　　者：许琛琛[1] 吴斯琪[1,2] 王勤美[1] 

机构地区：[1]温州医科大学附属眼视光医院,325027 [2]昆明医科大学附属儿童医院眼科,650100

出　　处：《中华眼视光学与视觉科学杂志》2015年第12期712-716,共5页Chinese Journal Of Optometry Ophthalmology And Visual Science

基　　金：浙江省医药卫生重大科技计划项目（WKJ-ZJ-1530）;温州市科技局资助项目（J20140014）

摘　　要：目的 探讨正常人群角膜上皮层厚度分布情况及其相关因素.方法 横断面研究.按照入选标准序贯选取年龄10～60岁、屈光度为＋0.50～-10.00 D且散光＜2.00 D的受检者199例（398眼）.应用RTVue 100-2傅立叶频域光学相干断层扫描仪（FD-OCT）测量6.0 mm范围内17个区域角膜及角膜上皮的平均厚度.采用方差分析各区域角膜上皮层厚度分布差异,t检验比较不同眼别和性别间的差异,并采用Pearson相关分析角膜上皮层厚度与眼别、性别、角膜补偿眼压（IOPcc）、等效球镜度（SE）、年龄的相关性.结果 右、左眼角膜中央区（半径1.0 mm区）角膜上皮层厚度分别为（54.51 ±3.40） μm、（54.34±3.28） μm,旁中央区（半径1.0～2.5 mm区）分别为（53.84±3.29）μm、（53.85±3.22）μm,周边区（半径2.5～3.0 mm区）分别为（53.08±3.07） μm、（53.27±3.11）μm,从中央区到周边区逐渐变薄,差异有统计学意义（F右=9.620,P＜0.01;F左=5.378,P＜0.01）.在同一半径范围内,上皮层厚度鼻侧大于颞侧,下方大于上方,差异均具有统计学意义（P＜0.01）.右、左眼各相应区域差异均无统计学意义（P＞0.05）.男性上皮层厚度大于女性,除了周边区颞上侧外,其余16个区域差异有统计学意义（P＜0.05）.女性角膜中央区（r=0.207,P＜0.05）以及旁中央区的鼻下（r=0.225,P＜0.05）、正下（r=0.276,P＜0.01）和颞下（r=0.282,P＜0.01）上皮层厚度与其对应区域的角膜厚度呈正相关.所有区域的上皮层厚度与IOPcc、SE和年龄无相关性.结论 正常人眼的角膜上皮层并不是均一分布,中央厚周边薄、下方厚上方薄、鼻侧厚颞侧薄,双眼以鼻子为中线呈镜像对称,男性厚于女性,女性角膜中央区与旁中央区下方上皮层厚度与角膜厚度成正相关.Objective To investigate the distribution characteristics and related factors of corneal epithelial thickness in a population with healthy eyes.Methods An epithelial thickness profile was measured by RTVue 100-2 Fourier-domain optical coherence topography （FD-OCT）, scanning across the central 6.0-mm diameter of the cornea of 199 patients with normal, healthy eyes.The corneal epithelial thickness was evaluated in 17 areas： 1） one central zone within 0-2.0 mm diameters, 2） eight paracentral zones from 2.0-5.0 mm diameters, and 3） eight peripheral zones from 5.0-6.0 mm diameters.The epithelial thickness for the right and left eyes of the same patient was compared.Correlations of epithelial thickness with gender, age, spherical equivalent （SE）, corneal-compensated intraocular pressure （IOPcc） and corneal thickness were calculated in 17 areas.Results The central, paracentral, and peripheral epithelial thickness averages were 54.51 ±3.40, 53.84±3.29, and 53.08±3.07 μm for right eyes and 54.34±3.28, 53.85±3.22 and 53.27±3.11 μm for left eyes.The average epithelial thickness map showed that the corneal epithelium was thicker nasally than temporally （P〈0.01）, thicker inferiorly than superiorly （P〈0.01） and thicker in the 2.0～5.0 mm diameter than in the 5.0～6.0 mm diameter （righteyes F=9.620, P〈0.01;lefteyes： F=5.387, P〈0.01）.All epithelial thickness indicators had statistically significant differences between males and females in the 16 areas （P〈0.05） except for the superior temporally at the peripheral zones.The epithelial thickness was greater in males than in females.There was no statistically significant difference between right and left eyes （P〉0.05）.The female epithelial thickness and corneal thickness showed positive correlations in the central zone （r=0.207, P〈0.05）.Positive correlations were also found in inferior temporally （r=0.282, P〈0.01）, inferiorly （r=0.276, P〈0.01） and inferior nasally （r=0.225, P〈0.05） at the paracen

关 键 词：体层摄影术 光学相干 厚度 角膜上皮层 横断面研究 

分 类 号：R779.65[医药卫生—眼科]