低分子量透明质酸功能与制备研究进展  

Research Progress in Function and Production of Low Molecular Weights of Hyaluronic Acid

作　　者：赖永勤 刘玉川[1] 周正东[1] 李学如[1] 

机构地区：[1]西南交通大学生命科学与工程学院,四川成都610031

出　　处：《食品与发酵科技》2015年第6期77-80,99,共5页Food and Fermentation Science & Technology

基　　金：四川省科技支撑项目(2012FZ0048)资助

摘　　要：透明质酸广泛应用于医药、化妆品和食品等领域,目前主要通过微生物发酵生产。透明质酸的生物活性和使用效果与其相对分子量相关。近年来,低分子量透明质酸在抗肿瘤、促进伤口愈合与血管生成、免疫调节、药物靶向等方面具有重要潜在应用价值,引起了人们的广泛关注。本文针对低分子量透明质酸生物活性功能以及制备方法等方面的研究进展进行了综述。Hyaluronic acid has been widely used in pharmaceuticals, cosmetics and food industry, which produced by microbial fermentation. The biological activity and use effect associate with its molecular weight. HA with low molecular weight and HA oligosaccharides have the function of anti-tumor, promoting wound healing, angiogenesis,immune regulation and so on. In this paper we review the progress on the function and application of the low molecular weight hyaluronic acid and its production in recent years.

关 键 词：低分子量透明质酸 功能与应用 制备 

分 类 号：TQ921[轻工技术与工程—发酵工程]