环指蛋白43基因及其在消化系统肿瘤中的功能  

Ring finger protein 43 gene and its function in digestive system cancer

作　　者：邱旺旺 杨治力[1] 郑起[1] 

机构地区：[1]上海交通大学附属第六人民医院普通外科,200233

出　　处：《国际肿瘤学杂志》2016年第1期56-59,共4页Journal of International Oncology

基　　金：国家自然科学基金，National Natural Science Foundation of China

摘　　要：环指蛋白43（RNF43）是一种重要的泛素链接酶.作为Wnt信号通路中的拮抗蛋白,RNF43具有重要的抗肿瘤作用.RNF43突变后会引起Wnt信号通路的异常激活,进而促进细胞的侵袭、转移与增殖.除此之外,在临床抗肿瘤的研究中发现,RNF43与Wnt通路相互作用的位点有望作为肿瘤治疗的分子靶标.近年来,随着相关研究的逐渐深入,RNF43的分子结构及其与Wnt通路中相关蛋白的作用机制已经逐渐明确.而在临床研究中,RNF43蛋白的类似物及相关疫苗也显示出RNF43在肿瘤治疗中的重要地位.Ring finger protein 43 （RNF43） is a ring-type E3 ubiquitin ligase.As a negative regulater of Wnt signaling pathway, RNF43 has an important anti-tumor effect.The mutation of RNF43 may cause abnormal activation of Wnt signaling pathway, and then promote invasion, metastasis and proliferation of tumor cell.In addition, the act of RNF43 protein in the Wnt signal pathway is expected to be a molecular target in the therapy of cancer.In recent years, with the gradual deepening of related research, the molecular structure of RNF43 protein and its mechanism of action with the Wnt pathway-related proteins have been gradually clear.In clinical, RNF43 protein analogs and related vaccine also show the important position in the therapy of cancer.

关 键 词：基因表达调控 消化系统肿瘤 基因 肿瘤抑制 环指蛋白43 

分 类 号：R735[医药卫生—肿瘤]