弥漫大B细胞淋巴瘤患者血清乳酸脱氢酶、β2-微球蛋白联合检测的临床意义  

Clinical significance of serum lactate dehydrogenase and β2-microglobulinin in patients with diffuse large B-cell lymphoma

作　　者：赵淑清[1] 李军民[2] 陈丽[2] 杨晨敏[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院卢湾分院血液科,上海200020 [2]上海交通大学医学院附属瑞金医院血液科,200025

出　　处：《临床肿瘤学杂志》2015年第12期1124-1127,共4页Chinese Clinical Oncology

基　　金：上海市卫计委青年科研基金项目(2007Y67);上海市黄浦区卫计委优秀青年人才培养计划(2014-2016)

摘　　要：目的探讨血清乳酸脱氢酶（LDH）、β2-微球蛋白（β2-MG）水平的联合检测对弥漫大B细胞淋巴瘤（DLBCL）的临床意义。方法选择2009年1月至2014年6月我院收治的初治DLBCL患者58例,分别采用速率法和放射免疫分析法检测血清LDH和β2-MG表达水平,并分析其与DLBCL临床病理特征的关系;同时观察化疗有效组患者治疗前后LDH和β2-MG表达水平的变化,评价其与疗效的关系。结果 LDH和β2-MG水平在Ⅲ~Ⅳ期、ECOG评分≥2以及有骨髓浸润的患者中均明显升高（P〈0.05）;〉60岁者的β2-MG水平高于≤60岁的患者（P〈0.05）;有全身症状（B症状）组LDH水平明显高于无B症状组（P〈0.05）;LDH和β2-MG水平均与性别无关。治疗有效患者化疗后LDH、β2-MG水平较化疗前下降,差异有统计学意义（P〈0.05）。结论联合检测血清LDH和β2-MG水平可作为判断DLBCL患者的临床分期、是否存在骨髓浸润及评价疗效的临床指标。Objective To investigate the clinical significance of serum levels of lactate dehydrogenase（ LDH） and β2-microglobulin（ β2-MG） in diffuse large B-cell lymphoma（ DLBCL）. Methods The serum levels of LDH and β2-MG of 58 patients with DLBCL were measured by rate method and radioimmunoassay. Besides,the clinicopathological characteristics of the patients such as gender,age,B symptoms,clinical stages,ECOG score of performance status（ ECOG-PS） and bone marrow invasion were summarized and anylyzed. Meanwhile,the association between the level change of LDH and β2-MG after chemotherapy and therapeutic effectiveness was also evaluated. Results The levels of LDH and β2-MG in the advanced stage group,ECOG≥2 group,bone marrow invasion group were significantly higher than those of their counterpart（ P〈0. 05）. The level of β2-MG in aged over 60 patients was higher than that of younger ones（ P〈0. 05）,but there was no statistical significance in the LDH level（ P〉0. 05）. The level of LDH in B symptoms group was higher than that of without B symptoms（ P〈0. 05）,but there was no statistical significance in the β2-MG level（ P〉0. 05）. There was no statistical significance about LDH and β2-MG levels in gender（ P〉0. 05）. The levels of LDH and β2-MG in positive response group significantly decreased after chemotherapy（ P〈0. 05）. Conclusion LDH and β2-MG can be taken as indicators in classifying the clinical phase and judging whether there is bone marrow infiltration or not,and evaluating the chemotherapeutic effectiveness of DLBCL patients.

关 键 词：弥漫大B细胞淋巴瘤 乳酸脱氢酶 Β2-微球蛋白 

分 类 号：R733.4[医药卫生—肿瘤]