Activation of less affected corticospinal tract and poor motor outcome in hemiplegic pediatric patients:a diffusion tensor tractography imaging study  

作　　者：Jin Hyun Kim Su Min Son 

机构地区：[1]Department of Physical Medicine and Rehabilitation,College of Medicine,Yeungnam University

出　　处：《Neural Regeneration Research》2015年第12期2054-2059,共6页中国神经再生研究（英文版）

基　　金：supported by 2013 Yeungnam University Research Grant

摘　　要：The less affected hemisphere is important in motor recovery in mature brains.However,in terms of motor outcome in immature brains,no study has been reported on the less affected corticospinal tract in hemiplegic pediatric patients.Therefore,we examined the relationship between the condition of the less affected corticospinal tract and motor function in hemiplegic pediatric patients.Forty patients with hemiplegia due to perinatal or prenatal injury（13.7±3.0 months）and 40 age-matched typically developing controls were recruited.These patients were divided into two age-matched groups,the high functioning group（20 patients）and the low functioning group（20 patients）using functional level of hemiplegia scale.Diffusion tensor tractography images showed that compared with the control group,the patient group of the less affected corticospinal tract showed significantly increased fiber number and significantly decreased fractional anisotropy value.Significantly increased fiber number and significantly decreased fractional anisotropy value in the low functioning group were observed than in the high functioning group.These findings suggest that activation of the less affected hemisphere presenting as increased fiber number and decreased fractional anisotropy value is related to poor motor function in pediatric hemiplegic patients.The less affected hemisphere is important in motor recovery in mature brains.However,in terms of motor outcome in immature brains,no study has been reported on the less affected corticospinal tract in hemiplegic pediatric patients.Therefore,we examined the relationship between the condition of the less affected corticospinal tract and motor function in hemiplegic pediatric patients.Forty patients with hemiplegia due to perinatal or prenatal injury（13.7±3.0 months）and 40 age-matched typically developing controls were recruited.These patients were divided into two age-matched groups,the high functioning group（20 patients）and the low functioning group（20 patients）using functional level of hemiplegia scale.Diffusion tensor tractography images showed that compared with the control group,the patient group of the less affected corticospinal tract showed significantly increased fiber number and significantly decreased fractional anisotropy value.Significantly increased fiber number and significantly decreased fractional anisotropy value in the low functioning group were observed than in the high functioning group.These findings suggest that activation of the less affected hemisphere presenting as increased fiber number and decreased fractional anisotropy value is related to poor motor function in pediatric hemiplegic patients.

关 键 词：nerve regeneration unaffected hemisphere HEMIPLEGIA corticospinal tract diffusiontensor imaging motor function neural regeneration 

分 类 号：R742[医药卫生—神经病学与精神病学]