ER、PR在分化型甲状腺癌组织中的表达及临床意义  

Expression and clinical significance of ER and PR in differentiated thyroid carcinoma tissue

作　　者：李励琦[1] 杭剑萍[1] 

机构地区：[1]江南大学附属无锡第四人民医院甲状腺乳腺外科,江苏无锡214000

出　　处：《川北医学院学报》2015年第6期816-819,共4页Journal of North Sichuan Medical College

摘　　要：目的:探讨雌激素受体(estrogen receptor,ER)及孕激素受体(progesterone receptor,PR)在分化型甲状腺癌组织中的表达及临床意义。方法:选取无锡第四人民医院病理科存档的甲状腺肿瘤标本98例为研究对象,采用免疫组化SP法检测98例甲状腺肿瘤中ER及PR的表达,并分析两者在甲状腺乳头状癌(papillary thyroid carcinoma,PTC)及甲状腺滤泡癌(follicular thyroid carcinoma,FTC)组织中的相关性。结果:ER和PR在PTC及FTC组织中的阳性表达率均显著高于甲状腺腺瘤和结节性甲状腺肿组织,差异有统计学意义(P<0.05、P<0.01);ER、PR在PTC及FTC组织中的表达均与性别、年龄密切相关(P<0.01)。ER、PR在PTC及FTC组织中的表达均呈显著正相关性(r=0.025,P=0.018;r=0.278,P=0.035)。结论:甲状腺肿瘤组织中ER及PR的表达可作为鉴别良恶性肿瘤的参考指标。Objective： To explore the expression and clinical significance of estrogen receptor（ ER） and progesterone receptor（ PR） in differentiated thyroid carcinoma tissue. Methods： A total of 98 samples with thyroid tumors archived in Department of Pathology in The Fourth People＇s Hospital of Wuxi were selected as research objects. The expression of ER and PR in the thyroid tumor tissues was respectively detected using immunohistochemical SP method,and their correlations in papillary thyroid carcinoma（ PTC） and follicular thyroid carcinoma（ FTC） tissues were analyzed. Results： The positive expression rates of ER and PR in PTC and FTC tissues were dramatically higher than in thyroid adenoma and nodular goiter tissues,with statistical significance（ P〈0. 05 or P〈0. 01）. The positive expression rates of ER and PR in the patients with PTC and 〈45 years old were also higher than in those ≥45 years old,and significant difference was presented（ P〈0. 01）. The expressions of ER and PR in PTC and FTC tissues had significantly positive correlations（ r = 0. 025,P = 0. 018; r = 0. 278,P = 0. 035）. Conclusion： The expression of ER and PR in thyroid tumor tissue can be used as a reference index in the identification of benign and malignant tumors.

关 键 词：雌激素受体 孕激素受体 甲状腺癌 免疫组化 

分 类 号：R736.1[医药卫生—肿瘤]