善宁对手术患者心率血压的影响  

THE RISING OF BLOOD PRESSURE AND HEART RATE BY INTRAOPERATIVE USING OF SANDOSTATIN

作　　者：方刚[1] 姚飞[1] 曾健滢[1] 汪媛[1] 李家亮[1] 牛立志[1] 刘建国[1] 徐克成[1] 

机构地区：[1]暨南大学医学院附属广州复大肿瘤医院,广东广州510665

出　　处：《现代医院》2015年第12期42-43,46,共3页Modern Hospitals

基　　金：2010年国家临床重点专科建设(编号:ZX001232)

摘　　要：目的 观察术中使用善宁对患者心率、舒张压、收缩压的影响。方法 20例手术肿瘤患者,麻醉平稳后采用善宁注射液0.1 mg静脉注射,在桡动脉直接动脉血压监测下记录给药前、给药后1,2,3,4,5,6,7,8,9,10,11,12,18 min心率、舒张压和收缩压的变化。结果 患者用药后1、2、3、4、5、6、7、8、9、10、11、12、18 min舒张压和收缩压显著高于用药前（P〈0.05）;患者用药后1、2、3、4、5、6、7、8、9、10、11、12、18 min心率与用药前相比无统计学差异。收缩压和舒张压变化趋势相似,均于用药后2 min达到峰值,然后下降,于用药后7~8 min达到稳定。结论 术中使用善宁可促使患者舒张压和收缩压升高,对心率无影响。Objective Sandostatin, as a synthetic somatostatin, had been used widespread for cancer patients. Sandostatins had the function to reduce visceral perfusion and decrease the pressure of portal vein. In this study, we observed the changing of blood pressure and heart rate by intraoperative using of sandostatin. Method Af ter anesthesia, sandostatin were injected intravenously in twenty cancer patients. Diastolic blood pressure and systolic blood pressure were recorded before delivery and every minute after delivery. Result After sandostatin injection, the patients diastolic blood pressure and systolic blood pressure were rising synchronously within 18 minute of injection, compared with before delivery （ all P 〈 0. 05 ）. The systolic and diastolic blood pressure reached the peak two minute after injection and fell back to a steady state 7 - 8min after injection. There is no significant differences of heart rate changing before and after sandostatin injection. Conclusion Based on this study, we found that the diastolic and systolic blood pressure can go up 18 minute after sandostatin injection in these twenty cancer patients. The drug sandostatin had no effect on patients heart rate changing.

关 键 词：善宁 心率 舒张压 收缩压 

分 类 号：R575.2[医药卫生—消化系统]