乳腺癌组织CCR7的表达及其与上皮间质转化的关系  

Expression of CCR7 and its correlation with epithelial-mesenchymal transition in breast carcinoma

作　　者：徐蕴[1] 张肇林 窦珊珊[1] 崔利德[1] 

机构地区：[1]济宁医学院基础学院,山东济宁272067 [2]蓬莱市人民医院,山东蓬莱265600

出　　处：《济宁医学院学报》2015年第6期394-396,402,共4页Journal of Jining Medical University

基　　金：2013年济宁医学院科研计划项目(编号:JY2013KJ014)

摘　　要：目的研究趋化因子受体-7（chemokine receptor 7,CCR7）在乳腺癌组织中的表达及临床意义,并探讨CCR7与上皮间质转化（epithelial mesenchymal transformation,EMT）的关系。方法采用免疫组织化学检测CCR7、EMT相关标志物转录因子Slug和N-cadherin的表达,分析CCR7与患者病理特征的关系。结果 1）CCR7在淋巴结转移组的表达明显高于无淋巴结转移组（χ~2=5.061,P〈0.05）;2）CCR7在人乳腺癌组织的表达随患者病理分期的增加（Ⅰ→Ⅳ）而增加;3）CCR7、Slug和N-cadherin在人乳腺癌组织中均呈高表达,阳性率分别为60.71%（34/56）、66.07%（37/56）、76.78%（43/56）;4）CCR7与Slug、N-cadherin在乳腺癌组织的表达均呈正相关（P〈0.05）。结论 CCR7在人乳腺癌组织中的表达与EMT的指标密切相关,可能是判断癌转移的特异性指标。Objective To investigate the association between the expression of CCR7 and clinical parameters in human breast carcinoma and analyze the relationship between CCR7 and the epithelial-mesenchymal transition（EMT）.Methods CCR7,Slug and N-cadherin were examined by immunohistochemistry in 56 cases of breast carcinoma tissues.The correlation between clinical parameters and CCR7 expression were retrospectively analyzed.Results 1）The expressions of CCR7 in lymph node metastasis group were significantly higher than those in the group that without lymph node metastasis（χ~2=5.061,P〈0.05）.2）The expression of CCR7 in human breast cancer increased with the increase of the pathological stage of the patients.3）High expressions of CCR7,Slug and N-cadherin were found in human breast carcinoma and the positive rate was 60.71%,66.07%and76.78%respectively.4）The CCR7 expression was significantly associated to Slug and N-cadherin（P〈0.001）.Conclusion CCR7 was closely related to EMT indicators（Slug and N-cadherin）in human breast carcinoma.CCR7 may play a role in the genesis of EMT in human breast carcinoma and be expected to become the biomarker of cancer metastasis.

关 键 词：CCR7 乳腺癌 SLUG N-CADHERIN 淋巴转移 

分 类 号：R737.9[医药卫生—肿瘤]