阿立哌唑与喹硫平对双相抑郁障碍患者各项神经功能的影响  

Effects of Aripiprazole and Quetiapine on Neurological Function in Patients with Bipolar Depression Disorder

作　　者：高作惠[1] 严峻[1] 胡晓华[1] 刘连忠[1] 周新芳[1] 林国荣[1] 李东霞[1] 

机构地区：[1]华中科技大学同济医学院附属精神卫生中心,武汉430022

出　　处：《中国药房》2016年第2期248-250,共3页China Pharmacy

摘　　要：目的：比较阿立哌唑与喹硫平对双相抑郁障碍患者各项神经功能的影响。方法：选取双相抑郁障碍患者100例,按随机数字表法分为阿立哌唑组和喹硫平组,各50例。阿立哌唑组患者采用阿立哌唑5 mg,bid;喹硫平组患者第1~3天给予喹硫平25mg,bid,之后每3天加量25 mg直至150 mg,bid。两组患者均治疗8周。治疗前及治疗后2、4、6、8周,分别对两组患者进行蒙哥马利抑郁量表（MADRS）、蒙特利尔认知功能评定量表（Mo CA）、简易智能精神状态评分表（MMSE）、日常生活能力量表（ADL）评分比较。结果：两组患者治疗后8周MADRS评分比较,差异无统计学意义（P〉0.05）;治疗后2、4、6、8周,阿立哌唑组患者治疗后8周Mo CA评分均高于喹硫平组,差异有统计学意义（P〈0.05）;治疗后,两组患者MMSE、ADL评分较治疗前均有明显改善,且治疗后8周,阿立哌唑组患者MMSE评分明显高于喹硫平组,ADL评分明显低于喹硫平组,差异有统计学意义（P〈0.05）。结论：阿立哌唑和喹硫平对于双相抑郁障碍患者具有明显的治疗效果,且阿立哌唑对抑郁障碍患者神经功能、精神状态以及基本思维能力改善明显优于喹硫平,而喹硫平则能明显提高患者日常生活的能力。OBJECTIVE：To compare the effects of aripiprazole and quetiapine on cognitive function in patients with bipolar depression.METHODS：100 patients with bipolar depression were selected and randomly divided into aripiprazole group and quetiapine group,with 50 cases in each group.Aripiprazole group was given aripiprazole 5 mg,bid;quetiapine group was given quetiapine 25 mg,bid,on 1st-3rd day,increasing 25 mg every 3 days until to 150 mg,bid.Both groups received 8 weeks of treatment.Before and after 2,4,6,8 weeks of treatment,MADRS,Mo CA,MMSE and ADL of 2 groups were recorded.RESULTS：There was no statistical significance in MADRS between 2 groups after 8 weeks of treatment（P〉0.05）.Mo CA of aripiprazole group was higher than that of quetiapine group after 2,4,6 and 8 weeks of treatment,with statistical significance（P〈0.05）.After treatment,MMSE and ADL of 2 groups were improved significantly compared to before treatment;MMSE of aripiprazole group was significantly higher than that of quetiapine group while ADL was significantly lower than quetiapine group after 8 weeks of treatment,with statistical significance（P〈0.05）.CONCLUSIONS：Quetiapine and aripiprazole has obvious curative effect on patients with bipolar depression,and the improvement effect of aripiprazole is better than quetiapine on cognitive function in patients with bipolar depression.

关 键 词：阿立哌唑 喹硫平 双相抑郁障碍 认知功能 精神状态 日常生活能力 

分 类 号：R749.053[医药卫生—神经病学与精神病学]