视神经脊髓炎与抗水通道蛋白4抗体研究进展  

Recent advance in relation of neuromyelitis optica with anti-aquaporin-4 antibody

作　　者：米芳[1] 贾宏阁[1] 

机构地区：[1]第四军医大学西京医院神经内科,西安710032

出　　处：《中华神经医学杂志》2016年第1期96-100,共5页Chinese Journal of Neuromedicine

摘　　要：视神经脊髓炎（NMO）是主要累及视神经和脊髓的中枢神经系统（CNS）自身免疫性脱髓鞘疾病。血清中抗水通道蛋白4（AQP4）抗体对NMO的临床诊断、早期治疗及预后判断意义重大。本文围绕抗AQP4抗体在NMO发病机制中的作用、检测方法及临床意义等方面的最新研究进展综述如下。Neuromyelitis optica （NMO） is an inflammatory demyelinating disorder of the central nervous system （CNS） that predominantly affects the optic nerve and spinal cord. It has long been controversial about the concept whether NMO is an independent disease, or a subtype of multiple sclerosis （MS）. In 2004, anti-AQP4 antibody was found in the sera of NMO patients, which gradually indicates that NMO is an independent disease different from MS. The discovery of anti-AQP4 antibody will not only contribute to the clinical diagnosis, early treatment and prognosis of NMO, but also make us do further research on NMO. We mainly reviewed the role of anti-AQP4 antibody in pathogenesis of NMO, detection methods and clinical significance of NMO.

关 键 词：视神经脊髓炎 抗水通道蛋白4抗体 脱髓鞘疾病 

分 类 号：R744.52[医药卫生—神经病学与精神病学]