盐酸环丙沙星分子印迹电化学传感器  

Molecularly Imprinted Electrochemical Sensor for Ciprofloxacin hydrochloride

作　　者：闫长领[1] 张春朵 樊宏哲[2] 陈玉娟[1] 李金[1] 刘珣[1] 王公轲[1] 

机构地区：[1]河南师范大学化学与化工学院,新乡453007 [2]新乡医学院第三附属医院心胸外科,新乡453000

出　　处：《化学通报》2016年第1期66-70,共5页Chemistry

基　　金：国家自然科学基金项目(21303044;21173071;21303043);高等学校重点科研项目(15A150058) 资助

摘　　要：本文将电化学合成与分子印迹技术相结合,采用循环伏安法在石墨电极表面,形成盐酸环丙沙星(CPX)分子印迹聚吡咯薄膜,制备了CPX分子印迹传感器。实验对传感器的制备条件进行了优化,用铁氰化钾作为活性电子探针,采用方波伏安法研究了传感器性能。结果表明,在1×10^(-8)~1×10^(-4)mol/L范围内,峰电流与CPX浓度负对数呈良好的线性关系,检出限(S/N=3)为3.5×10^(-9)mol/L。传感器对模板分子CPX选择性强,重现性和稳定性好,置于室温下15d峰电流强度无明显变化。Molecular imprinting technique was used to prepare electrochemical sensor for ciprofloxacin hydrochloride（ CPX） by electrochemical polymerization on the surface of graphite electrode using pyrrole as functional monomer. The effect of preparation conditions on sensor was investigated and the performances of the sensor were measured by square wave voltammetry（ SWV） with ferricyanide as an electrochemical probe. The results showed that the peak current was linear to the negative logarithm of CPX concentration in the range from 1.0×10-8 to 1.0×10-4mol / L with a detection limits（S/N=3） of 3.5×10-9mol / L. The sensor has good selectivity,reproducibility and stability for template CPX and the peak current of the sensor did not clearly change after stored for 15 days.

关 键 词：分子印迹 盐酸环丙沙星 吡咯 电化学传感器 

分 类 号：O657.1[理学—分析化学] TS207.5[理学—化学]