肺外淋巴结淋巴管肌瘤病13例临床病理分析  

Clinicopathologic features of lymphangioleiomyomatosis in extrapulmonary lymph nodes in 13 cases

作　　者：蒋冰[1] 黄波[1] 刘丽男[1] 刘骞[1] 王正[1] 

机构地区：[1]辽宁省肿瘤医院病理科,沈阳110042

出　　处：《中华实用诊断与治疗杂志》2016年第1期65-67,共3页Journal of Chinese Practical Diagnosis and Therapy

基　　金：沈阳市科技攻关项目(F10-149-41)

摘　　要：目的探讨肺外淋巴结淋巴管肌瘤病(lymphangiomyomatosis,LAM)的临床病理学特征。方法回顾性分析13例肺外淋巴结LAM患者的临床资料,采用免疫组织化学法检测LAM组织标本中波形蛋白(vimentin,Vim)、平滑肌肌动蛋白(smooth muscle actin,SMA)、雌激素受体(estrogen receptor,ER)、孕激素受体(progesterone receptor,PR)、黑素体(human melanoma black 45,HMB45)、D2-40及Ki67表达情况。结果免疫组织化学染色结果显示,LAM细胞表达SMA和Vim,Ki67<5%;上皮样LAM细胞表达HMB45,窦样腔隙内衬扁平内皮细胞表达D2-40,仅肠系膜淋巴结LAM少数肿瘤细胞表达ER及PR,盆腔淋巴结LAM均未见确切阳性表达。结论肺外淋巴结LAM临床罕见,免疫组织化学检测Vim、SMA、ER、PR、HMB45、D2-40及Ki67的表达情况有助于诊断。Objective To investigate the clinicopathologic features of lymphangioleiomyomatosis （LAM） in extrapulmonary lymph nodes. Methods The clinical data of 13 cases of LAM in extrapulmonary lymph nodes were retrospectively analyzed. The expressions of vimentin （Vim）, smooth muscle actin （SMA）, estrogen receptor （ER）, progesterone receptor （PR）, human melanoma black 45 （HMB45）, D2-40 and Ki67 were detected by immunohistochemical method. Results Immunohistochemical results showed positive SMA, Vim and Ki67〈5% in LAM cells, positive HMB45 in epithelial LAM, positive D2-40 in sinuseidal endothelial cells, and positive ER and PR in only a few tumor cells in LAM in mesenteric nodes, and LAM in pelvis nodes showed no abnormal. Conclusion LAM in extrapulmonary lymph nodes is extremely rare. Detection of Vim, SMA, ER, PR, HMB45, D2-40 and Ki67 by immunohistochemical method will contribute to the diagnosis of LAM in extrapulmonary lymph nodes.

关 键 词：淋巴管肌瘤病 肺外淋巴结 临床病理特征 免疫组织化学检查 

分 类 号：R734.2[医药卫生—肿瘤]