健脾益肾法对行FOLFOX6化疗的晚期大肠癌患者癌因性疲乏和证候积分及生存状态的影响  

Effect of Spleen Invigorating and Kidney Nourishing Therapy on Cancer-related Fatigue, Syndrome Integral and Survival Status of Patients With Advanced Colorectal Cancer Undergoing FOLFOX6 Chemotherapy

作　　者：李志明[1] 

机构地区：[1]广州中医药大学,广东省第二中医院肿瘤科,广东省广州市510405

出　　处：《中国全科医学》2015年第36期4492-4495,共4页Chinese General Practice

基　　金：广东省建设中医药强省基金项目(20152005);广东省第二中医院(广东省中医药工程技术研究院)院级科研创新基金项目(201315)

摘　　要：目的观察健脾益肾法对行FOLFOX6化疗的晚期大肠癌(CRC)患者癌因性疲乏(CRF)、证候积分及生存状态的影响。方法选取2012年4月—2014年12月于广东省第二中医院住院且符合纳入与排除标准的CRC合并CRF患者60例为研究对象。采用随机数字表法将其分为治疗组和对照组,各30例。两组患者均行FOLFOX6化疗,同时治疗组患者全程辅助健脾益肾方。评价并比较两组患者CRF评分、证候积分评分和生存状态评分。结果治疗后治疗组患者CRF评分总分、行为方面、躯体方面、认知方面得分低于对照组(P<0.05)。治疗后两组患者情感方面得分比较,差异无统计学意义(P>0.05)。对照组患者治疗后躯体方面得分高于治疗前(P<0.05);治疗组患者治疗后CRF评分总分、行为方面、躯体方面、认知方面得分低于治疗前(P<0.05)。治疗后治疗组患者证候积分评分低于对照组(P<0.05)。治疗组患者治疗后证候积分评分低于治疗前(P<0.05)。治疗后治疗组患者生存状态评分高于对照组(P<0.05)。对照组患者治疗后生存状态评分低于治疗前(P<0.05)。结论健脾益肾法对行FOLFOX6化疗的CRC患者CRF、证候积分及生存状态均有改善作用,其在CRC患者CRF治疗中占有主导性地位,但仍提倡综合治疗的模式。Objective To observe the effect of spleen invigorating and kidney nourishing therapy on cancer - related fatigue （CRF）, syndrome integral and survival status of patients with advanced colorectal cancer undergoing FOLFOX6 chemotherapy. Methods 60 patients with advanced colorectal cancer complicated with CRF who were admitted into Guangdong Second Traditional Chinese Medicine Hospital from April 2012 to December 2014 and who accorded with the inclusion and exclusion criteria were enrolled in the study. Using random number table, the subjects were divided into treatment group and control group, with 30 patients in each group. The two groups both received FOLFOX6 chemotherapy. At the same time, the treatment group was administrated with spleen invigorating and kidney nourishing therapy as auxiliary therapy through the whole chemotherapy. The scores of CRF, syndrome integral and survival status were evaluated and compared between the two groups. Results After treatment, the treatment group was lower （ P 〈 0. 05 ） than the control group in total score, the scores of behavior, body and cognition, and no significant difference （ P 〉 0. 05 ） was noted＂ between the two groups in the score of emotion. The control group had higher （ P 〈 0. 05 ） score of body after treatment than that before treatment ; the treatment group had lower （P 〈 0. 05） scores of behavior, body and recognition and lower total score than those before treatment. After treatment, the treatment group was lower （P 〈 0. 05） than the control group in the score of syndrome integral, and the treatment group had lower （ P 〈 0. 05 ） score of syndrome integral than that before treatment. After treatment, the treatment group was higher （ P 〈0, 05 ） than the control group in the score of survival status. The control group had lower （ P 〈 0. 05 ） score of survival status than that before treatment. Conclusion Spleen invigorating and kidney nourishing therapy have positive effect on CRF, syndrome integral and surv

关 键 词：结直肠肿瘤 抗肿瘤联合化疗方案 证候 健脾益肾法 癌因性疲乏 

分 类 号：R735.34[医药卫生—肿瘤]