薏苡仁提取物对C57小鼠肝癌模型IL-6抑制作用的实验研究  

Experimental Study on Inhibiting Effect of Coix Seed Extract on IL-6 of C57 Mice Hepatoma Model

作　　者：沈丰[1] 孙少华[1] 吴红伟[1] 胡洪生[1] 周文波[1] 王飞[1] 

机构地区：[1]湖北医药学院附属东风医院肝胆外科,湖北十堰442000

出　　处：《中国普外基础与临床杂志》2016年第1期38-41,共4页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的探讨薏苡仁提取物对C57小鼠肝癌模型IL-6的抑制作用。方法使用化学致癌物质二乙基亚硝胺(DEN)建立肝癌小鼠模型,给予肝癌小鼠模型薏苡仁提取物治疗,观察C57小鼠肝癌模型形成过程中的成瘤率、肿瘤生长及血清IL-6水平的变化。结果 C57小鼠腹腔注射薏苡仁提取物注射液后肝癌模型成瘤率为55.6%,明显低于DEN组的87.5%(P<0.01);肿瘤直径为(0.3±0.05)cm,明显低于DEN组的(0.8±0.06)cm(P<0.01);C57小鼠在接受薏苡仁提取物治疗后血清IL-6水平明显低于DEN组(P<0.01)。结论薏苡仁提取物能有效抑制C57小鼠肝癌模型的成瘤率及肿瘤的生长,能降低血清IL-6水平。Objective To discuss the effects of coix seed extract injection on rate of tumor of C57 mice liver cancer model, tumor size, and serum IL-6. Methods Using chemical carcinogens diethyl nitrosamine （DEN） to establish the mice model of liver cancer, liver cancer mouse model to coix seed extract was given observation of C57 mice liver cancer model come tumor formation rate, tumor growth, and the change of serum IL-6. Results C57 mice after intraperitoneal injection of coix seed extract injection model of liver cancer tumor rate （55.6%） significantly lower than the DEN group （87.5%）, P〈0.01; tumor diameter [（0.3±0.05） cm] was lower than that in group DEN [ （0.8±0.06） cm], P〈0.01. The serum level of IL-6 in C57 mice after treated with coix seed extract significantly lower than that in group DEN （P〈0.01）. Conclusion Coix seed extract can effectively inhibit the tumor rate and the growth of tumor in hepatocellular carcinoma model of C57 mice, and decrease the level of serum IL-6.

关 键 词：薏苡仁提取物 C57小鼠 肝癌 白细胞介素-6 

分 类 号：R735.7[医药卫生—肿瘤] R-332[医药卫生—临床医学]