血清PARP-1蛋白高表达在胃癌中的临床意义  

The clinical significance of serum PARP-1 protein high expression in gastric cancer

作　　者：王睿[1] 王岚[2] 黎明新[1] 朱明艳[1] 刘新[2] 

机构地区：[1]沈阳医学院附属中心医院检验科,辽宁沈阳110024 [2]沈阳医学院病原生物学教研室,辽宁沈阳110034

出　　处：《中国癌症杂志》2015年第12期972-977,共6页China Oncology

摘　　要：背景与目的:PARP-1与恶性肿瘤密切相关。该研究旨在考察血清PARP-1蛋白水平在胃癌发生、发展中的临床意义。方法:收集145例胃癌患者血样以及112例健康体检者血清样本,应用酶联免疫吸附试验法检测血清中幽门螺杆菌(Helicobacter pylori,Hp)特异性Ig A和PARP-1蛋白水平,并分析血清PARP-1蛋白水平与胃癌临床特征的相关性。结果:与健康人相比,胃癌患者血清PARP-1蛋白显著增高[(407±139)pg/mL vs(258±120)pg/mL,P=0.014];Hp阳性胃癌患者PARP-1的表达水平显著高于Hp阴性患者(P<0.001);血清PARP-1蛋白水平与胃癌患者的胃癌家族史(P=0.033)和饮酒史(P=0.015)有着显著正相关性;与血清PARP-1蛋白阴性的患者相比,PARP-1蛋白阳性的胃癌患者的总体生存期显著缩短(P=0.011);多变量COX回归分析未发现血清PARP-1蛋白水平为影响胃癌患者总体生存期的独立风险因素。结论:血清PARP-1蛋白高表达可能参与胃癌的发生、发展,抑制PARP-1有可能成为治疗胃癌的潜在新靶点。Background and purpose： PARP-1 is closely related to malignant tumors. This study aimed to explore the clinical significance of serum level of PARP-1 protein in onset and progression of gastric cancer. Methods： The serum samples from 145 patients with gastric cancer and 112 healthy check-up cases were collected. The serum HP specificity IgA and PARP-1 protein levels were detected using enzyme-linked immunosorbent assay method. The correlation of serum PARP-1 protein levels with clinical characteristics of gastric cancer was analyzed. Results： Compared with healthy people, serum PARP-1 protein levels were significantly higher in gastric cancer patients [（407 ±139） pg/mL vs （258 ± 120） pg/mL, P=0.014）. Serum PARP-1 protein levels were significantly higher in Hp （＋） gastric cancer patients than those in patients with Hp （-） （P〈0.001）. Serum PARP-1 protein levels were positively correlated with family gastric cancer history （P=0.033） and alcohol intake history （P=0.015） in gastric cancer patients. Compared with serum protein PARP-1 negative patients, PARP-1 protein positive patients had a significantly shorter cancer-free survival （P=0.011）. However serum PARP-1 protein level was not found to be an independent risk factor for the overall survival of gastric cancer patients using multivariate COX regression. Conclusion： High expression of serum PARP-1 protein may be involved in the pathogenesis and progression of gastric cancer. Inhibition of PARP-1 may be potential new target for the treatment of gastric cancer.

关 键 词：胃癌 PARP-1 血清 幽门螺杆菌 

分 类 号：R735.2[医药卫生—肿瘤]