肿瘤光学分子成像技术研究进展  

Progress of Optica I Molecular Imaging Technology of Tumor

作　　者：马文娟[1] 刘佩芳[1] 胡从依[1] 王红彬[1] 

机构地区：[1]天津医科大学肿瘤医院乳腺影像诊断科,国家肿瘤临床医学研究中心,乳腺癌防治教育部重点实验室,天津市肿瘤防治重点实验室,天津300060

出　　处：《中国医学计算机成像杂志》2015年第6期605-608,共4页Chinese Computed Medical Imaging

基　　金：国家自然科学基金;No.61108081;天津市抗癌重大科技专项;No.12ZCDZSY16000~~

摘　　要：肿瘤光学分子成像技术是近年发展起来的新兴技术,在生命科学研究中占有重要地位。其原理为采用荧光报告基团或荧光染料标记的目的细胞,通过灵敏的光学成像仪器,检测活体生物体内细胞生物学行为。依对比度产生机制有两个主要模态:生物体自发光成像和荧光层析成像。光学分子成像技术具有无创、可多次重复、实时活体成像、灵敏、安全等优势,但目前还在发展的初期,是分子影像学领域面临突破的重点研究方向,它的发展必将为生命科学和临床医学研究提供革命性的新方法和手段。Optical molecular imaging technology of tumor with bioluminescence and fluorescence is a newly-- emerging technology developed in recent years. The target cells were first tagged with fluorescence reporter gene or fluorescent dyes, and then the fluorescence was detected by sensitive optics apparatus. According to the contrast effect mechanism, this technology can be divided into two types： bioluminescence imaging and fluorescence molecular tomography. This technology is a non-invasive, repeatable method with more sensitive and safety, and can be applied in vivo and real time. At present, this technology is still in the initial stages of development, and it is the key research direction of the molecular imaging. It will provide a revolutionary new method and means for life science and clinical medical research.

关 键 词：肿瘤 分子成像 生物体自发光成像 荧光层析成像 

分 类 号：R730.4[医药卫生—肿瘤]