探讨血清HE4、CA125与TSGF检测对卵巢癌诊断的价值  

Value of serum HE4,CA125 and TSGF detection in diagnosis of ovariancancer

作　　者：李楠[1] 姚亚超[1] 李亚红[1] 张珍[1] 李泽泳[1] 邱厚匡[1] 严芳[1] 

机构地区：[1]广东省第二人民医院检验医学部,广东广州510317

出　　处：《国际检验医学杂志》2016年第1期60-61,64,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨血清人附睾上皮分泌蛋白(HE4)、糖类抗原125(CA125)和肿瘤特异性生长因子(TSGF)检测在卵巢癌诊断中的价值。方法采用ELISA法检测HE4、化学发光法检测血清CA125,全自动生化法检测TSGF水平。采集85例卵巢癌患者、60例卵巢良性肿瘤患者及55例健康体检者血清,分析各标志物单项和联合检测对卵巢癌的诊断价值。结果卵巢癌患者血清HE4、CA125和TSGF水平均明显高于卵巢良性疾病患者组和健康对照组(P<0.05),HE4、CA125和TSGF在卵巢癌组的阳性检出率分别为64.7%、72.9%和77.6%,与良性卵巢肿瘤组和健康对照组相比,差异有统计学意义(P<0.05)。在卵巢癌单项标志物检测中,血清TSGF的灵敏度(77.8%)优于CA125、HE4;而血清HE4的特异度最高。HE4和TSGF联合检测的约登指数最高(64.8%)。血清HE4、TSGF联合检测对卵巢癌诊断的敏感度和阴性预测值均高于单项检测,分别为88.2%、82.1%,且高于HE4、CA125联合检测。结论在卵巢癌的早期诊断中血清HE4、TSGF联合检测比血清HE4、CA125联合检测更有意义。Objective To investigate the value of human epididymis secretory protein4（HE4）,carbohydrate antigen（CA125）and tumor specific growth factor（TSGF）in the diagnosis of ovarian cancer.Methods Serum was collected from 85 cases of ovarian cancer,60 cases of benign ovarian tumor and 55 individuals undergoing healthy physical examination.Serum HE4 level was determined by ELISA,serum CA125 level was measured by CLIA and the TSGF level was detected by the automatic biochemical assay.The diagnostic values of single marker detection and their combined detection were analyzed.Results Serum HE4,CA125 and TSGF expression levels in the patients with ovarian cancer were significantly higher than those in the patients with benign ovarian diseases and healthy controls（P〈0.05）.The positive rates of serum HE4,CA125 and TSGF in the ovarian cancer group were 64.7%,72.9%and 77.6%respectively,which showing the statistical difference compared with those in the benign ovarian tumor group and the healthy control group.In the detection of single marker,the sensitivity of serum TSGF（77.8%）was superior to that of CA125 and HE4,while the specificity of serum HE4 was highest.The Youden index for the combination detection of HE4 and TSGF was highest（64.85%）.The sensitivity and negative predict value of the combination detection of HE4 and TSGF for diagnosing ovarian cancer were higher than those of the single marker detection,which were 88.2% and 82.1% and higher than those of the combination detection of HE4 and CA125.Conclusion Compared with the combination detection of HE4 and CA125,the combination detection of HE4 and TSGF has more significance in the early diagnosis of ovarian cancer.

关 键 词：人附睾上皮分泌蛋白4 糖类抗原125 肿瘤特异性生长因子 卵巢癌 约登指数 

分 类 号：R737.31[医药卫生—肿瘤]