ARD1在鼻咽癌中的表达及临床意义研究  

Study on expression and clinical significance of ARD1 in nasopharyngeal carcinoma

作　　者：贾培荣[1] 曾妍 郑军[1] 杨国军[1] 徐江[1] 

机构地区：[1]石河子大学医学院第一附属医院口腔科,新疆石河子832000 [2]石河子大学医学院生化教研室,新疆石河子832000

出　　处：《重庆医学》2016年第2期183-185,188,共4页Chongqing medicine

基　　金：国家自然科学基金资助项目(81560473);新疆建设兵团博士基金项目(2014BB021);高层次人才启动资金项目(RCZX201330)

摘　　要：目的检测ARD1在鼻咽部炎性组织、鼻咽癌组织及其各亚组之间的表达情况并探讨其临床意义。方法应用免疫组织化学SP法检测鼻咽癌组织(56例)、鼻咽部炎性组织(20例)中ARD1的表达情况,并分析ARD1的表达与年龄、性别、分化程度、临床分期、肿瘤转移等临床参数的相关性。结果 ARD1在鼻咽部炎性组织、鼻咽癌组织中的阳性率分别为10.00%(2/20)、55.35%(31/56),ARD1在鼻咽癌组织中的表达水平明显高于其在鼻咽部炎性组织中的表达,差异有统计学意义(P<0.05);ARD1的表达与鼻咽癌组织的分化程度相关(P<0.05),在分化差的组织中表达上调;但与患者年龄、性别、临床分期、肿瘤转移差异无统计学意义(P>0.05)。结论 ARD1在鼻咽癌组织中高表达,且与肿瘤分化程度密切相关,提示ARD1可能与鼻咽癌的发生发展有关,但具体如何发挥作用仍需做进一步的深入研究。Objective To detect and explore the expression of ARD1 and its clinical significance in the nasopharyngeal inflammatory tissue,nasopharyngeal carcinoma group and its subgroups. Methods Expression of ARD1 in nasopharyngeal carcinoma （56 cases） and nasopharyngeal inflammatory tissue （20 cases） were detected by immunohistochemical staining SP,the correlation between the expression of ARD1 and age, gender, histological grade, TNM clinical stage and tumor metastasis were analysed. Results The positive expression rate of ARD1 were 10.00% （2/20） ,55.35% （31/56） in the nasopharyngeal inflammatory tissue and nasopharyngeal carcinoma, respectively. The expression level of ARD1 in nasopharyngeal carcinoma was significantly higher than in the nasopharyngeal inflammatory tissue, the difference was significant （P〈0. 05） ;expression of ARDI in the nasopharyngeal carcinoma was correlated with the histological grade of nasopharyngeal carcinoma（P〈0.05） and the expression was increased in poor differenciation tissue. But there was no statistical difference between the expression of ARD1 and the patient＇s age, gender, TNM clinical stage,tumor metastasis（P〉0. 05）. Conclusion The expression of ARD1 is high in nasopharyngeal carcinoma,and has a closely correlation with diffferentiation level of tumor,which suggested that ARD1 may be involved in the the occurrence and development of nasopharyngeal carcinoma. However,further research needs to be done for its mechanism in the nasopharyngeal carcinoma.

关 键 词：鼻咽肿瘤 ARD1 细胞分化 免疫组织化学 

分 类 号：R739.63[医药卫生—肿瘤]