检测ROC1在卵巢恶性上皮性肿瘤组织中的表达及临床意义研究  

Expression and clinical significance of ROC1 in women with epithelial ovarian cancer

作　　者：李娜[1] 孙丽君[1] 李东林[2] 刘颂[1] 高家志[1] 

机构地区：[1]遵义医学院附属医院妇科,贵州遵义563000 [2]贵州省人民医院妇科,贵阳550002

出　　处：《重庆医学》2016年第2期202-204,共3页Chongqing medicine

基　　金：贵州省科技厅联合基金资助项目(黔科合J字LKZ[2012]50号)

摘　　要：目的探究ROC1在卵巢恶性上皮性肿瘤组织的表达及临床意义,为卵巢上皮性恶性肿瘤的基因治疗提供新的思路。方法选取2005年10月至2007年10月在遵义医学院附属医院行卵巢癌手术并进行了长达5年随访的261例卵巢癌患者,对卵巢癌组织及相应周围正常组织中ROC1mRNA及蛋白表达水平进行检测,并将结果与患者的预后之间的相关性进行统计分析。结果 ROC1在卵巢癌组织中过度表达,而在相对应周围正常组织中几乎不表达;ROC1表达水平高低与患者的生存率存在负相关性。结论卵巢癌患者中ROC1表达水平越高,预后越差。Objective To investigate the expression and clinical significance of ROC1 in ovarian cancer tissues,to provide new ideas for the gene therapy of ovarian cancer. Methods 261 women with ovarian cancer underwent resection from December 2005 to December 2007 in the Affiliated Hospital of Zunyi Medical College and with 5 years follow-up were enrolled. ROC1 mRNA transcription and protein expression level of ovarian cancer tissue and surrounding normal tissue were tested,and later the correlation between the results and patient＇s prognosis was statistically analyzed. Results ROC1 in ovarian cancer tissue was over-expressed, but almost no expression in surrounding normal ovarian carcinoma;ROC1 expression levels had a negative correlation with the survival rate of the patients. Conclusion ROC1 in ovarian cancer tissue was over-expressed,but almost no expression in surrounding normal ovarian carcmoma;ROC1 expression levels had a negative correlation with the survival rate of the patients.

关 键 词：ROC1 卵巢肿瘤 基因疗法 预后 存活率 

分 类 号：R737.31[医药卫生—肿瘤]