氟斑牙青少年尿氟与唾液氟及菌斑氟的相关性分析  

Multiple regression analysis of urinary fluoride, saliva and plaque fluoride levels of adolescents dental fluorosis

作　　者：于阳阳[1] 赵伟[2] 刘晓燕[1] 邹冬荣 杨晓昀[1] 刘荣[1] 于晓峰[1] 营杰[1] 

机构地区：[1]华北石油管理局总医院口腔科,任丘062552 [2]华北石油管理局总医院眼科,任丘062552

出　　处：《中华地方病学杂志》2016年第1期23-26,共4页Chinese Journal of Endemiology

摘　　要：目的研究氟斑牙青少年尿氟与唾液氟及菌斑氟的相关性，评价氟斑牙程度、唾液氟及菌斑氟对尿氟的影响。方法选择河北省任丘市华油供应中学为调查点，测定饮用水水氟含量，选取200名初一在校青少年学生作为研究对象，采用Dean法检查氟斑牙患病情况；按照氟斑牙程度分为轻、中、重度氟斑牙组及无氟斑牙组（n=52、40、28、80），应用离子选择性电极法测定尿氟、唾液氟及菌斑氟。4组间进行方差齐性检验及方差分析，对氟斑牙程度、尿氟、唾液氟及菌斑氟进行相关分析，并应用多元回归分析氟斑牙程度、唾液氟及菌斑氟对尿氟的影响。结果饮用水水氟为（2．20±0．40）mg／L；轻、中、重度氟斑牙组青少年尿氟、唾液氟及菌斑氟均高于无氟斑牙组[（1．55±0．88）、（1．94±0．77）、（2．74±0．83）比（0．32±0．20）mg／L，（4．44±1．62）、（8．09±0．93）、（10．72±0．99）比（0．02±0．01）mg／L，（31．77±6．09）、（57．98±1．83）、（65．98±2．78）比（13．06±2．11）μg／g，P均〈0．05]。氟斑牙组（包括轻、中、重度氟斑牙组）青少年尿氟与唾液氟及菌斑氟的相关性有统计学意义[相关系数（r）=0．245、0．440，P均〈0．05]，唾液氟与菌斑氟的相关性有统计学意义（r=0．849，P〈0．01）。氟斑牙程度与尿氟、唾液氟、菌斑氟的相关性有统计学意义（r=0．497、0．896、0．924，P均〈0．01）。以尿氟为因变量，以氟斑牙程度、菌斑氟及唾液氟为自变量，构建回归模型，方程为Y=1．357＋1．618x1＋0．001x2—0．331x3±0．69。结论氟斑牙患者全身氟代谢水平与口腔局部氟含量相关，且氟斑牙程度、口腔内唾液氟及菌斑氟共同影响尿氟。Objective The purpose of this study was to study the correlation between dental fluorosis, saliva and plaque fluoride levels and urinary fluoride values in adolescents dental fluorosis. Methods A middle school was chosen as a survey point in the study. Two hundred adolescents were examined the degree of dental fluorosis by Dean＇s method. These adolescents were divided into four groups according to the severity of fluorosis （n = 52, 40, 28 and 80）. Fluoride ion specific electrode was used to measure the fluoride levels in dental plaque, saliva, urinary and drinking water. The differences were analyzed by ANOVA. Correlation of the fluoride levels between dental plaque, saliva, urine and the degree of dental fluorosis were analyzed by the method of multiple linear regression. Results The average fluoride content of drinking water was （2.20 ± 0.40） mg/L. Compared with controls, the fluoride concentrations in dental plaque, saliva and urine were higher in light, medium and severe dental fluorosis groups [（1.55 ±0.88）, （1.94 ± 0.77）, （2.74 ± 0.83） than （0.32 ± 0.20） mg/L; （4.44 ± 1.62）, （8.09 ± 0.93）, （10.72 ± 0.99） than （0.02 ±0.01） mg/L; （31.77 ± 6.09）, （57.98 ± 1.83）, （65.98 ± 2.78） than （13.06 ± 2.11） μg/g, all P 〈 0.05]. Urinary fluoride was correlated with fluoride in saliva and dental plaque （r = 0.245, 0.440, all P 〈 0.05）. Saliva fluoride was correlated with fluoride in dental plaque （r = 0.849, P 〈 0.01）. The degree of dental fluorosis was correlated with fluoride in urine and saliva （r = 0.497, 0.896, 0.924, all P 〈 0.01）. The multiple linear regression equation between fluoride in urine and the degree of dental fluorosis, fluoride in dental plaque and saliva was as follow： y = 1.357 ＋ 1.618x1 ＋ 0.001x2 - 0.331x3 ±0.69. Conclusions The metabolism of fluoride in body is related with oral fluoride repository in adolescents dental fluorosis. Fluoride in urine is influenced by plaque fluoride level, saliva fluoride

关 键 词：氟中毒 牙 尿 唾液 牙菌斑 

分 类 号：R781[医药卫生—口腔医学] R599.1[医药卫生—临床医学]