Eda和Edar在哺乳动物毛囊形成和生长发育中的作用研究进展  

Progress on Roles of Eda and Edar in Mammalian Hair Follicle Formation and Development

作　　者：高淑媛[1] 于秀菊[1] 程笳琪 刘宁[1] 赫晓燕[1] 

机构地区：[1]山西农业大学动物科技学院,山西太谷030801

出　　处：《动物医学进展》2016年第1期81-84,共4页Progress In Veterinary Medicine

基　　金：国家自然科学基金项目(31172283);山西农业大学2009年引进人才科研启动项目(XB2009020)

摘　　要：毛囊是皮肤的附属器官,发生在胚胎期早期,是由表皮的角质细胞和间充质间的上皮相互作用产生的,真皮成纤维细胞聚集形成毛囊乳头。毛囊形态发生分为3个阶段,即诱导、器官形成和细胞分化。毛发周期包括毛发生长初期(生长阶段)、毛发生长中期(退化阶段)和静止期(静止阶段)。外胚层发育不全基因(Eda)及其受体Edar表达于毛囊的不同发育时期,在野生型小鼠胚胎只表达在外胚层,而在发育中小鼠则定位在外胚层和毛囊中,毛囊的准确定位和间隔是通过外异蛋白受体Edar-BMP信号和转录的相互作用来调控的。Eda和Edar对于毛囊的正常发育有很大的作用,且在毛囊发育周期的不同阶段其作用也不同。The hair follicle（HF）,produced in the early embryo stage,is a skin appendage that develops as a result of interactions between epidermal,keratinocytes and mesenchymal epithelium,and a cluster of dermal fibroblasts forms the follicular papilla.The stages of morphogenesis are broadly classified into：induction,organogenesis and cytodifferentiation.The hair cycle includes anagen（growth phase）,catagen（regression phase）and telogen（resting phase）.Ectoderm hypoplasia gene（Ectodysplasin-A,Eda）and its receptor Edar express in different development period of hair follicles.In wild-type mouse,Eda and Edar expressions are confined to the ectoderm while they are localized in the ectoderm and hair follicles for developing mouse skin.Proper positioning and spacing of HF are mediated via the ectodysplasin receptor Edar-BMP signaling and transcriptional interactions.Eda and Edar have a great effect for the normal development of the hair follicles,and have different roles in different stages of hair follicle growth cycle.

关 键 词：毛囊 Eda基因 Edar基因受体 基板 

分 类 号：S852.16[农业科学—基础兽医学]