帕罗西汀联合无抽搐电休克治疗伴自杀倾向抑郁症的临床疗效及安全性  

Efficacy and safety of modified electroconvuisive combined with paroxetine in the treatment of depression with attempted suicide

作　　者：陈黎明[1] 况利[1] 李大齐[2] 张代江[3] 侯云跃 

机构地区：[1]重庆医科大学附属第一医院心理卫生中心,重庆400016 [2]重庆医科大学附属大学城医院心理卫生中心,重庆400016 [3]重庆市精神卫生中心男一病区,重庆400016

出　　处：《中国临床药理学杂志》2016年第2期153-155,共3页The Chinese Journal of Clinical Pharmacology

摘　　要：目的观察帕罗西汀联合无抽搐电休克治疗伴自杀倾向抑郁症患者的临床疗效及安全性。方法 128例伴有自杀倾向的抑郁症患者分为试验组64例和对照组64例。对照组口服帕罗西汀,每天1次,初始剂量为20 mg·d^(-1),根据患者病情及对药物的反应调节剂量;试验组在对照组的基础上给予无抽搐电休克治疗,每周3次。2组治疗周期均为4周。治疗前后用汉密尔顿抑郁量表(HAMD)、Beck自杀意念量表评分,并观察不良反应发生情况。结果试验组患者治疗1周后HAMD、Beck自杀意念量表评分分别为(19.65±7.43),(9.19±3.47),显著优于对照组的(24.62±4.57),(12.43±5.28),治疗2,3,4周后各项评分均优于对照组,2组差异有统计学意义(P<0.05)。试验组有效率(96.9%)显著高于对照组(90.6%,P<0.05);试验组痊愈率(62.5%)显著高于对照组(34.4%,P<0.05)。试验组和对照组患者不良反应发生率分别为6.25%,9.38%,差异无统计学意义(P>0.05)。结论无抽搐电休克联合帕罗西汀治疗伴自杀倾向抑郁症患者起效快,可快速改善患者症状,且不增加不良反应发生率。Objective To investigate the efficacy and safety of modified electroconvuisive therapy combined with paroxetine in the treatment of depression patients with attempted suicide andprovide the basis for clinical treatment. Methods A total of 128 cases of depression patients with attempted suicide were divided into treatment group（ n = 64） and control group（ n = 64）. Patients in treatment group were treated with modified electroconvuisive therapy combined with paroxetine,3 times per week,12 times totally,and patients in control group were treated with paroxetine,30- 40 mg·d^-1,once a day for 4 weeks. Before and after treatment,Hamilton depression（ HAMD） scale,Beck score,and adverse reactions of the two groups were observed,the efficacy and safety of two groups were evaluated. Results After treatment 1 week,the HAMD and Beck score of the patients in treatment group were（ 19. 65 ± 7. 43） and（ 9. 19 ± 3. 47）,respectively,significantly better than those of control group（ 24. 62 ± 4. 57）,（ 12. 43 ± 5. 28）. In the following 2- 4 weeks after treatment,the HAMD and Beck score of treatment group were also better than control group. The effective rate in treatment group（ 96. 9%）was higher than that in control group（ 90. 6%,P〈0. 05）. The complete recovery rate in treatment group is 62. 5%,which was higher than 34. 4% in control group（ P〈0. 05）. The incidence rate of adverse reactions in treatment group and control group were 6. 25%,9. 38%,respectively,the difference had no statistical significance（ P〉0. 05）.Conclusion Modified electroconvuisive therapy combined with paroxetine in the treatment of depression patients with attempted suicide is superior to the single effect of paroxetine,and does not increase the risk of adverse reactions.

关 键 词：抑郁症 无抽搐电休克 帕罗西汀 汉密尔顿抑郁量表 

分 类 号：R749.05[医药卫生—神经病学与精神病学] R971.43[医药卫生—临床医学]