缩泉丸对膀胱过度活动症大鼠膀胱充盈期盆神经放电的影响  

Effects of Suoquan Wan on bladder pelvic nerve firing during intravesical instillation of OAB rats

作　　者：赖焕玲[1] 陈鹏宇[1] 段晓瑾[1] 徐伟君[1] 雷玉婧 郭茜[1] 吴清和[1] 黄萍[1] 操红缨[1] 

机构地区：[1]广州中医药大学,广东广州510006

出　　处：《中国病理生理杂志》2016年第1期151-155,共5页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.81202982)

摘　　要：目的:研究缩泉丸对膀胱过度活动症(OAB)大鼠膀胱容量、压力及盆神经放电的影响,探讨缩泉丸对OAB大鼠膀胱感觉功能的作用。方法:SD雌性大鼠分别进行膀胱出口梗阻手术以复制OAB模型,随机分为OAB模型组、假手术组和缩泉丸高、中、低剂量组,给药4周后,以尿动力仪观察灌注过程中膀胱容量、压力及非排尿性收缩的变化,以多通道生理记录仪检测灌注过程中盆神经放电的变化。结果:OAB大鼠盆神经放电模式表现为放电频率先于压力达到峰值,而后压力达到峰值时,放电频率趋于平台或下降。OAB模型大鼠膀胱充盈过程中盆神经放电频率明显增强,膀胱压力上升,容量增加,非排尿性收缩增多;缩泉丸的干预能降低盆神经的放电冲动,减少神经放电增强引起的逼尿肌非排尿性收缩,降低膀胱压力,并呈剂量依赖性。结论:缩泉丸对OAB大鼠膀胱感觉功能的调节可能是其治疗OAB的机制之一。AIM： To investigate the effects of Suoquan Wan（ SQW） on bladder volume,pressure and pelvic nerve firing in overactive bladder（ OAB） rats. METHODS： The OAB rat model was established by bladder outlet obstruction,and the rats in sham group received sham surgery. The OAB rats were randomly divided into OAB model group,highdose SQW group,middle-dose SQW group and low-dose SQW group. After 4 weeks of treatment,an aerodynamic instrument was used to measure the pressure,volume and non-voiding contraction of all the rats. The pelvic nerve firing signal was recorded by the BL-420 E multichannel recorder. RESULTS： The frequency of pelvic nerve firing increased to the peak before pressure. When the pressure reached the peak value,the firing signal remainded or reduced. The firing,pressure,volume and non-voiding contraction in the OAB model rats were significantly increased compared with the sham rats.After treated with SQW,the firing and pressure was dose-dependently decreased. CONCLUSION： The regulatory effect of SQW on the pelvic nerve may be one of the mechanisms for treating OAB.

关 键 词：缩泉丸 膀胱过度活动症 膀胱出口梗阻 盆神经放电 

分 类 号：R363[医药卫生—病理学] R285.5[医药卫生—基础医学]